"Propylthiouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
| Descriptor ID |
D011441
|
| MeSH Number(s) |
D03.383.742.698.875.842.708
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Propylthiouracil".
Below are MeSH descriptors whose meaning is more specific than "Propylthiouracil".
This graph shows the total number of publications written about "Propylthiouracil" by people in this website by year, and whether "Propylthiouracil" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Propylthiouracil" by people in Profiles.
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Sarkar S, Bischoff LA. Management of Hyperthyroidism during the Preconception Phase, Pregnancy, and the Postpartum Period. Semin Reprod Med. 2016 11; 34(6):317-322.
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Chaiamnuay S, Moster M, Katz MR, Kim YN. Successful management of a pregnant woman with a TSH secreting pituitary adenoma with surgical and medical therapy. Pituitary. 2003 Sep; 6(2):109-13.
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Ross AD, Dey I, Janes N, Israel Y. Effect of antithyroid drugs on hydroxyl radical formation and alpha-1-proteinase inhibitor inactivation by neutrophils: therapeutic implications. J Pharmacol Exp Ther. 1998 Jun; 285(3):1233-8.
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Kantharia BK, Richards HB, Battaglia J. Reversible dilated cardiomyopathy: an unusual case of thyrotoxicosis. Am Heart J. 1995 May; 129(5):1030-2.
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Ross AD, Varghese G, Oporto B, Carmichael FJ, Israel Y. Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically. Biochem Pharmacol. 1995 Mar 30; 49(7):979-89.
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Carmichael FJ, Orrego H, Saldivia V, Israel Y. Effect of propylthiouracil on the ethanol-induced increase in liver oxygen consumption in awake rats. Hepatology. 1993 Aug; 18(2):415-21.
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Smeyne RJ, Goldowitz D. Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Brain Res Dev Brain Res. 1990 Jul 01; 54(2):282-6.
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Kawasaki T, Carmichael FJ, Giles G, Saldivia V, Israel Y, Orrego H. Effects of propylthiouracil and methimazole on splanchnic hemodynamics in awake and unrestrained rats. Hepatology. 1989 Sep; 10(3):273-8.
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Rachamin G, Okuno F, Israel Y. Inhibitory effect of propylthiouracil on the development of metabolic tolerance to ethanol. Biochem Pharmacol. 1985 Jul 01; 34(13):2377-83.
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Rachamin G, Britton RS, Macdonald JA, Israel Y. The inhibitory effect of testosterone on the development of metabolic tolerance to ethanol. Alcohol. 1984 Jul-Aug; 1(4):283-91.