"Pyrimidine Dimers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.
| Descriptor ID |
D011740
|
| MeSH Number(s) |
D03.383.742.686.600 D13.695.578.424.600 D13.695.740.600
|
| Concept/Terms |
Pyrimidine Dimers- Pyrimidine Dimers
- Dimers, Pyrimidine
- Cyclobutane-Pyrimidine Dimers
- Cyclobutane Pyrimidine Dimers
- Dimers, Cyclobutane-Pyrimidine
Thymine-Cyclobutane Dimer- Thymine-Cyclobutane Dimer
- Dimer, Thymine-Cyclobutane
- Thymine Cyclobutane Dimer
- Thymine-Thymine Cyclobutane Dimer
- Cyclobutane Dimer, Thymine-Thymine
- Dimer, Thymine-Thymine Cyclobutane
- Thymine Thymine Cyclobutane Dimer
- Thymine Dimers
- Dimers, Thymine
|
Below are MeSH descriptors whose meaning is more general than "Pyrimidine Dimers".
Below are MeSH descriptors whose meaning is more specific than "Pyrimidine Dimers".
This graph shows the total number of publications written about "Pyrimidine Dimers" by people in this website by year, and whether "Pyrimidine Dimers" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyrimidine Dimers" by people in Profiles.
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Bohm KA, Morledge-Hampton B, Stevison S, Mao P, Roberts SA, Wyrick JJ. Genome-wide maps of rare and atypical UV photoproducts reveal distinct patterns of damage formation and mutagenesis in yeast chromatin. Proc Natl Acad Sci U S A. 2023 03 07; 120(10):e2216907120.
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Sivapragasam S, Stark B, Albrecht AV, Bohm KA, Mao P, Emehiser RG, Roberts SA, Hrdlicka PJ, Poon GMK, Wyrick JJ. CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma. EMBO J. 2021 10 18; 40(20):e107795.
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Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapic-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 2019 08; 26(8):695-703.
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Fouquerel E, Barnes RP, Wang H, Opresko PL. Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA. Methods Mol Biol. 2019; 1999:295-306.
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Brown AJ, Mao P, Smerdon MJ, Wyrick JJ, Roberts SA. Nucleosome positions establish an extended mutation signature in melanoma. PLoS Genet. 2018 11; 14(11):e1007823.
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Mao P, Brown AJ, Esaki S, Lockwood S, Poon GMK, Smerdon MJ, Roberts SA, Wyrick JJ. ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. Nat Commun. 2018 07 06; 9(1):2626.
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Fouquerel E, Opresko PL. Convergence of The Nobel Fields of Telomere Biology and DNA Repair. Photochem Photobiol. 2017 01; 93(1):229-237.
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Mao P, Wyrick JJ, Roberts SA, Smerdon MJ. UV-Induced DNA Damage and Mutagenesis in Chromatin. Photochem Photobiol. 2017 01; 93(1):216-228.
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Mao P, Smerdon MJ, Roberts SA, Wyrick JJ. Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9057-62.
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Liu H, Tuchinda P, Fishelevich R, Harberts E, Gaspari AA. Human in vitro skin organ culture as a model system for evaluating DNA repair. J Dermatol Sci. 2014 Jun; 74(3):236-41.