Thomas Jefferson University

Pawan Sharma

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shah SD, Nayak AP, Sharma P, Villalba DR, Addya S, Huang W, Shapiro P, Kane MA, Deshpande DA. Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice. Am J Respir Cell Mol Biol. 2023 01; 68(1):23-38. PMID: 36067041.
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    2. Klionsky DJ. Diversity, equity and inclusion in autophagy research. Autophagy. 2022 12; 18(12):2765-2768. PMID: 36369701.
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    3. Sharma P, Alizadeh J, Juarez M, Samali A, Halayko AJ, Kenyon NJ, Ghavami S, Zeki AA. Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis. Cells. 2021 06 30; 10(7). PMID: 34209019.
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    4. Seyfoori A, Shokrollahi Barough M, Mokarram P, Ahmadi M, Mehrbod P, Sheidary A, Madrakian T, Kiumarsi M, Walsh T, McAlinden KD, Ghosh CC, Sharma P, Zeki AA, Ghavami S, Akbari M. Emerging Advances of Nanotechnology in Drug and Vaccine Delivery against Viral Associated Respiratory Infectious Diseases (VARID). Int J Mol Sci. 2021 Jun 28; 22(13). PMID: 34203268.
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    5. Thimmuri D, P A S, N P S, Khan A, Gawali B, Rajdev B, Adhikari C, V R, Sharma P, Naidu V. Hispolon inhibits RANKL induced osteoclast differentiation in vitro. Immunol Lett. 2021 03; 231:35-42. PMID: 33428992.
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    6. McAlinden KD, Eapen MS, Lu W, Sharma P, Sohal SS. The Ill Effects of IQOS on Airway Cells: Let's Not Get Burned All Over Again. Am J Respir Cell Mol Biol. 2020 08; 63(2):269-270. PMID: 32735165.
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    7. McAlinden KD, Eapen MS, Lu W, Sharma P, Sohal SS. The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L585-L595. PMID: 32726146.
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    8. McAlinden KD, Eapen MS, Ghavami S, Sohal SS, Sharma P. Altered Calcium in Ciliary Dysfunction: Potential Role of Endoplasmic Reticulum Stress and Ciliophagy. Am J Respir Cell Mol Biol. 2019 Dec;61(6):794-795. doi: 10.1165/rcmb.2019-0157LE. PubMed PMID: 31774335. 2019.
    9. Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, Hansbro PM, Sohal SS. Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Lab Invest. 2019 Feb;99(2):150-157. doi: 10.1038/s41374-018-0146-0. Epub 2018 Nov 19. Review. PubMed PMID: 30451982. 2019.
    10. Eapen MS, Sharma P, Sohal SS. Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD. Eur Respir J. 2019 Oct;54(4). doi: 10.1183/13993003.01641-2019. Print 2019 Oct. PubMed PMID: 31601722. 2019.
    11. Emami A, Shojaei S, da Silva Rosa SC, Aghaei M, Samiei E, Vosoughi AR, Kalantari F, Kawalec P, Thliveris J, Sharma P, Zeki AA, Akbari M, Gordon JW, Ghavami S. Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition. Eur J Pharmacol. 2019 Nov 5;862:172616. doi: 10.1016/j.ejphar.2019.172616. Epub 2019 Aug 23. PubMed PMID: 31449810. 2019.
    12. McAlinden KD, Sohal SS, Sharma P. There can be smoke without fire: warranted caution in promoting electronic cigarettes and heat not burn devices as a safer alternative to cigarette smoking. ERJ Open Res. 2019 Jul;5(3). doi: 10.1183/23120541.00114-2019. eCollection 2019 Jul. PubMed PMID: 31423449; PubMed Central PMCID: PMC6689670. 2019.
    13. Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, Hansbro PM, Sohal SS. Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics. Int J Chron Obstruct Pulmon Dis. 2019;14:1603-1610. doi: 10.2147/COPD.S208428. eCollection 2019. PubMed PMID: 31409985; PMCID: PMC6645357. 2019.
    14. Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS. New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways. Clin Sci (Lond). 2019 Jul 31;133(14):1663-1703. doi: 10.1042/CS20181009.PubMed PMID: 31346069. 2019.
    15. Lu W, Sharma P, Eapen MS, Sohal SS . Inhaled corticosteroids attenuate epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis. Eur Respir J. 2019 Jul;54(1). doi: 10.1183/13993003.00778-2019. Print 2019 Jul. PubMed PMID: 31296782. 2019.
    16. Eapen MS, Gaikwad AV, Thompson IE, Lu W, Myers S, Sharma P, Sohal SS. The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases. J Thorac Dis. 2019 May;11(Suppl 9):S1139-S1142. doi: 10.21037/jtd.2019.04.44. PubMed PMID: 31245065; PubMed Central PMCID: PMC6560594. 2019.
    17. Sohal SS, Eapen MS, Naidu VGM, Sharma P. IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette. ERJ Open Res. 2019 Feb; 5(1). PMID: 30775377.
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    18. Saha P, Johny E, Dangi A, Shinde S, Brake S, Eapen MS, Sohal SS, Naidu V, Sharma P . Impact of Maternal Air Pollution Exposure on Children's Lung Health: An Indian Perspective. Toxics. 2018 Nov 16;6(4). doi: 10.3390/toxics6040068. Review. PubMed PMID: 30453488; PubMed Central PMCID: PMC6315719. 2018.
    19. Eapen MS, Hansbro PM, Larsson-Callerfelt AK, Jolly MK, Myers S, Sharma P, Jones B, Rahman MA, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS . Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities. Drugs. 2018 Nov;78(16):1717-1740. doi: 10.1007/s40265-018-1001-8. Review. PubMed PMID: 30392114. 2018.
    20. Tonga KO, King GG, Farah CS, Thamrin C, Tang FS, Santos J, Sharma P, Chapman DG, Oliver BG . Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma. Respir Res. 2018 Sep 17;19(1):176. doi: 10.1186/s12931-018-0880-2. PubMed PMID: 30223904; PubMed Central PMCID: PMC6142701. 2018.
    21. Eapen MS, Myers S, Lu W, Tanghe C, Sharma P, Sohal SS . sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics. Biomarkers. 2018 Nov;23(7):709-711. doi: 10.1080/1354750X.2018.1479772. Epub 2018 Jun 19. PubMed PMID: 29781727. 2018.
    22. Comas M, Gordon CJ, Oliver BG, Stow NW, King G, Sharma P, Ammit AJ, Grunstein RR, Phillips CL . A circadian based inflammatory response – implications for respiratory disease and treatment. Sleep Science and Practice. 2017 December; 1(18). doi: 10.1186/s41606-017-0019-2. 2017.
    23. Sharma P, Jha A, Stelmack GL, Detillieux K, Basu S, Klonisch T, Unruh H, Halayko AJ . Characterization of the dystrophin-glycoprotein complex in airway smooth muscle: role of d-sarcoglycan in airway responsiveness. Can J Physiol Pharmacol. 2015 Mar;93(3):195-202. doi: 10.1139/cjpp-2014-0389. Epub 2015 Jan 14. PubMed PMID: 25692961. 2015.
    24. Boardman C, Chachi L, Gavrila A, Keenan CR, Perry MM, Xia YC, Meurs H, Sharma P . Mechanisms of glucocorticoid action and insensitivity in airways disease. Pulm Pharmacol Ther. 2014 Dec;29(2):129-43. doi: 10.1016/j.pupt.2014.08.008. Epub 2014 Sep 9. Review. PubMed PMID: 25218650. 2014.
    25. Ghavami S, Sharma P, Yeganeh B, Ojo OO, Jha A, Mutawe MM, Kashani HH, Los MJ, Klonisch T, Unruh H, Halayko AJ . Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. Biochim Biophys Acta. 2014 Jul;1843(7):1259-71. doi: 10.1016/j.bbamcr.2014.03.006. Epub 2014 Mar 15. PubMed PMID: 24637330. 2014.
    26. Yeganeh B, Wiechec E, Ande SR, Sharma P, Moghadam AR, Post M, Freed DH, Hashemi M, Shojaei S, Zeki AA, Ghavami S . Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease. Pharmacol Ther. 2014 Jul;143(1):87-110. doi: 10.1016/j.pharmthera.2014.02.007. Epub 2014 Feb 26. Review. PubMed PMID: 24582968; PubMed Central PMCID: PMC4005604. 2014.
    27. Moodley T, Wilson SM, Joshi T, Rider CF, Sharma P, Yan D, Newton R, Giembycz MA. Phosphodiesterase 4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells: a novel mechanism for the clinical efficacy of roflumilast in severe chronic obstructive pulmonary disease. Mol Pharmacol. 2013 Apr; 83(4):894-906. PMID: 23389862.
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    28. Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60. PMID: 22551156.
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    29. Ghavami S, Yeganeh B, Stelmack GL, Kashani HH, Sharma P, Cunnington R, Rattan S, Bathe K, Klonisch T, Dixon IM, Freed DH, Halayko AJ. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell Death Dis. 2012 Jun 21; 3:e330. PMID: 22717585.
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    30. Halayko AJ, Sharma P. . Airway smooth muscle cells. In: Inflammation and Allergy Drug Design. Holgate ST, Izuhara K, Wills-Karp M, editors. Oxford, England: Wiley-Blackwell, John Wiley & Sons; 2011. Chapter 12; p.163-174. 344p. 2011.
    31. Hashemi M, Sharma P, Eshraghi M, Naderi M, Moazeni-Roodi A, Mehrabifar H, Taheri M . Alpha-1 Antitrypsin: It’s Role in Health and Disease. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 2010; 9:279-288. 2010.
    32. Halayko A, Sharma P . S100A8/A9 as a pro-inflammatory cytokine in obstructive airway disease via the multi-ligand receptor, RAGE. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry. 2009; 8(4):306-317. 2009.
    33. Dastidar SG, Ray A, Shirumalla R, Rajagopal D, Chaudhary S, Nanda K, Sharma P, Seth MK, Balachandran S, Gupta N, Palle V . Pharmacology of a novel, orally active PDE4 inhibitor. Pharmacology. 2009;83(5):275-86. doi: 10.1159/000209608. Epub 2009 Mar 25. PubMed PMID: 19321962. 2009.
    34. Sharma P, Halayko AJ . Emerging molecular targets for the treatment of asthma. Indian J Biochem Biophys. 2009 Dec;46(6):447-60. Review. PubMed PMID: 20361708. 2009.
    35. Shirumalla RK, Sharma P, Dastidar SG, Paliwal JK, Kakar S, Varshney B, Singh Saini G, Sattigeri V, Salman M, Ray A . Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor. Inflamm Res. 2008 Mar;57(3):135-43. doi: 10.1007/s00011-007-7149-4. PubMed PMID: 18369577. 2008.
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