"Pyroptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type of programmed cell death associated with infection by intracellular pathogens. It is characterized by INFLAMMASOME formation; activation of CASPASE 1; and CYTOKINES mediated inflammation.
| Descriptor ID |
D000069292
|
| MeSH Number(s) |
G04.146.160.530
|
| Concept/Terms |
Pyroptosis- Pyroptosis
- Pyroptoses
- Pyroptotic Cell Death
- Cell Death, Pyroptotic
- Cell Deaths, Pyroptotic
- Death, Pyroptotic Cell
- Deaths, Pyroptotic Cell
- Pyroptotic Cell Deaths
- Inflammatory Apoptosis
- Apoptoses, Inflammatory
- Apoptosis, Inflammatory
- Inflammatory Apoptoses
- Caspase-1 Dependent Cell Death
- Caspase 1 Dependent Cell Death
|
Below are MeSH descriptors whose meaning is more general than "Pyroptosis".
Below are MeSH descriptors whose meaning is more specific than "Pyroptosis".
This graph shows the total number of publications written about "Pyroptosis" by people in this website by year, and whether "Pyroptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyroptosis" by people in Profiles.
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Varney SD, Erkes DA, Mersky GL, Mustafa MU, Chua V, Chervoneva I, Purwin TJ, Alnemri E, Aplin AE. Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma. Mol Cancer Res. 2025 04 01; 23(4):350-362.
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Vernon M, Wilski NA, Kotas D, Cai W, Pomante D, Tiago M, Alnemri ES, Aplin AE. Raptinal Induces Gasdermin E-Dependent Pyroptosis in Na?ve and Therapy-Resistant Melanoma. Mol Cancer Res. 2022 12 02; 20(12):1811-1821.
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Chavez L, Meguro J, Chen S, de Paiva VN, Zambrano R, Eterno JM, Kumar R, Duncan MR, Benny M, Young KC, Dietrich WD, Brambilla R, Wu S, Schmidt AF. Circulating extracellular vesicles activate the pyroptosis pathway in the brain following ventilation-induced lung injury. J Neuroinflammation. 2021 Dec 29; 18(1):310.
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Nagai H, Kirino Y, Nakano H, Kunishita Y, Henmi R, Szymanski AM, Yoshimi R, Ombrello MJ, Nakajima H. Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease. Rheumatology (Oxford). 2021 08 02; 60(8):3888-3895.
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Mayes-Hopfinger L, Enache A, Xie J, Huang CL, K?chl R, Tybulewicz VLJ, Fernandes-Alnemri T, Alnemri ES. Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nat Commun. 2021 07 27; 12(1):4546.
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Erkes DA, Cai W, Sanchez IM, Purwin TJ, Rogers C, Field CO, Berger AC, Hartsough EJ, Rodeck U, Alnemri ES, Aplin AE. Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis. Cancer Discov. 2020 02; 10(2):254-269.
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Rogers C, Erkes DA, Nardone A, Aplin AE, Fernandes-Alnemri T, Alnemri ES. Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nat Commun. 2019 04 11; 10(1):1689.
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Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun. 2017 01 03; 8:14128.