"beta-Arrestin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A beta-arrestin that functions in the down-regulation of signaling by G-PROTEIN-COUPLED RECEPTORS. It is also a major regulator of INSULIN signaling via the ERK 1-2 PATHWAY, and many other signaling processes, especially in NEURONS and LEUKOCYTES.
| Descriptor ID |
D000071559
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| MeSH Number(s) |
D12.644.360.024.098.525.500 D12.776.157.057.005.525.500 D12.776.476.024.104.525.500 D12.776.543.090.525.500
|
| Concept/Terms |
beta-Arrestin 1- beta-Arrestin 1
- beta Arrestin 1
- Arrestin-2
- Arrestin 2
- Arrestin, beta 1
- beta 1 Arrestin
- ARRB1 Protein
|
Below are MeSH descriptors whose meaning is more general than "beta-Arrestin 1".
Below are MeSH descriptors whose meaning is more specific than "beta-Arrestin 1".
This graph shows the total number of publications written about "beta-Arrestin 1" by people in this website by year, and whether "beta-Arrestin 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "beta-Arrestin 1" by people in Profiles.
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Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120.
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Shah SD, Lind C, De Pascali F, Penn RB, MacKerell AD, Deshpande DA. In silico identification of a ?2-adrenoceptor allosteric site that selectively augments canonical ?2AR-Gs signaling and function. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214024119.
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Tompkins E, Mimic B, Cuevas-Mora K, Schorsch H, Shah SD, Deshpande DA, Benovic JL, Penn RB, Pera T. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2022 11; 67(5):550-561.
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De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. ?2 -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the ?2 -adrenoceptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022 10; 179(19):4692-4708.
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Luo J, De Pascali F, Richmond GW, Khojah AM, Benovic JL. Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4. J Biol Chem. 2022 02; 298(2):101551.
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Ippolito M, Benovic JL. Biased agonism at ?-adrenergic receptors. Cell Signal. 2021 04; 80:109905.
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Yoo SM, Bhardwaj A, Benovic JL. Arresting Developments in Biased Signaling. Trends Pharmacol Sci. 2020 06; 41(6):387-389.
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Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. FASEB J. 2015 Oct; 29(10):4227-35.
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Tian X, Kang DS, Benovic JL. ?-arrestins and G protein-coupled receptor trafficking. Handb Exp Pharmacol. 2014; 219:173-86.
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Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):493-8.