"Soluble Guanylyl Cyclase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
| Descriptor ID |
D000071756
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| MeSH Number(s) |
D08.811.520.650.600.750 D12.644.360.350.500 D12.776.476.350.500
|
| Concept/Terms |
Soluble Guanylyl Cyclase- Soluble Guanylyl Cyclase
- Cyclase, Soluble Guanylyl
- Guanylyl Cyclase, Soluble
- Soluble Guanylate Cyclase
- Cyclase, Soluble Guanylate
- Guanylate Cyclase, Soluble
- Nitric Oxide-Sensitive Guanylyl Cyclase
- Nitric Oxide Sensitive Guanylyl Cyclase
- Receptor, Nitric Oxide
- Nitric Oxide Receptor
- Oxide Receptor, Nitric
- Nitric Oxide Receptors
- Oxide Receptors, Nitric
|
Below are MeSH descriptors whose meaning is more general than "Soluble Guanylyl Cyclase".
Below are MeSH descriptors whose meaning is more specific than "Soluble Guanylyl Cyclase".
This graph shows the total number of publications written about "Soluble Guanylyl Cyclase" by people in this website by year, and whether "Soluble Guanylyl Cyclase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Soluble Guanylyl Cyclase" by people in Profiles.
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Singh A, Mohanty I, Singh J, Rattan S. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G23-G33.
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Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clert? M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156.
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Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes. Cancer. 2012 May 01; 118(9):2532-40.
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Dreieicher E, Beck KF, Lazaroski S, Boosen M, Tsalastra-Greul W, Beck M, Fleming I, Schaefer L, Pfeilschifter J. Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1. J Am Soc Nephrol. 2009 Sep; 20(9):1963-74.
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Gong L, Pitari GM, Schulz S, Waldman SA. Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity. Curr Opin Hematol. 2004 Jan; 11(1):7-14.