Proof of Concept Study

"Proof of Concept Study" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An empirical investigation which pertains to the development of prototypes or models that demonstrate the feasibility of novel concepts, ideas, principles, schema or their practical application.

Descriptor ID	D000075082
MeSH Number(s)	H01.770.644.578
Concept/Terms	Proof of Concept Study Proof of Concept Study Concept Study Proof Study Proof, Concept Proof of Concept Investigation Concept Investigation Proof Investigation Proof, Concept Proof of Concept Research Concept Research Proof Concept Research Proofs Research Proof, Concept Proof of Concept Testing Concept Testing Proof Concept Testing Proofs Testing Proof, Concept Testing Proofs, Concept Proof of Concept Experiment Concept Experiment Proof Concept Experiment Proofs Experiment Proof, Concept Proof of Concept Approach Approach Proof, Concept Approach Proofs, Concept Concept Approach Proof Concept Approach Proofs Proof of Concept Studies Proof of Concept Prototype Proof of Concept Prototype Concept Prototype Proof Concept Prototype Proofs Prototype Proof, Concept Proof of Concept Model Concept Model Proof Concept Model Proofs Model Proof, Concept Proof of Concept Evaluation Proof of Concept Evaluation Concept Evaluation Proof Concept Evaluation Proofs Evaluation Proof, Concept Proof of Concept Demonstration Concept Demonstration Proof Demonstration Proof, Concept

Below are MeSH descriptors whose meaning is more general than "Proof of Concept Study".

Natural Sciences [H]
Natural Science Disciplines [H01]
Science [H01.770]
Research [H01.770.644]
Proof of Concept Study [H01.770.644.578]

Below are MeSH descriptors whose meaning is related to "Proof of Concept Study".

Below are MeSH descriptors whose meaning is more specific than "Proof of Concept Study".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proof of Concept Study" by people in this website by year, and whether "Proof of Concept Study" was a major or minor topic of these publications.

Bar chart showing 19 publications over 8 distinct years, with a maximum of 6 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2017	0	1	1
2018	0	1	1
2019	1	5	6
2020	0	2	2
2021	0	4	4
2022	0	1	1
2023	0	1	1
2024	1	2	3

Below are the most recent publications written about "Proof of Concept Study" by people in Profiles.

Gerratana L, Davis AA, Foffano L, Reduzzi C, Rossi T, Medford A, Clifton K, Shah AN, Bucheit L, Velimirovic M, Bandini S, Dai CS, Wehbe F, Gradishar WJ, Behdad A, Ulivi P, Ma CX, Puglisi F, Bardia A, Cristofanilli M. Integrating machine learning-predicted circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in metastatic breast cancer: A proof of principle study on endocrine resistance profiling. Cancer Lett. 2025 Jan 28; 609:217325.

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Jindal N, Sharma P, Punia S, Dass M, Anthwal D, Gupta RK, Bhalla M, Singhal R, Behera A, Yadav R, Sethi S, Dhooria S, Aggarwal AN, Haldar S. Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study. Tuberculosis (Edinb). 2025 Jan; 150:102578.

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Amabile AH, Hulcher TA, Figueroa-Perez M, Reich MR. Hoop Stress Elicited at Medial Tibial Crural Fascia Attachment During Passive Dorsiflexion: A Proof-of-Concept Study for Medial Tibial Stress Syndrome Causation. J Am Podiatr Med Assoc. 2024 Sep-Oct; 114(5).

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Kayastha D, Wiznia D, Manes RP, Omay SB, Khoury T, Rimmer R. 3D printing for virtual surgical planning of nasoseptal flap skull-base reconstruction: A proof-of-concept study. Int Forum Allergy Rhinol. 2023 11; 13(11):2073-2075.

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Mayer NH, Ferraro M, Pauloski-Hunt D, Chervoneva I. Capacity for Hand-as-a-Holder Function of the Spastic Combination Hand: A Proof-of-Concept Study. Am J Phys Med Rehabil. 2022 03 01; 101(3):298-302.

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Kers J, B?low RD, Klinkhammer BM, Breimer GE, Fontana F, Abiola AA, Hofstraat R, Corthals GL, Peters-Sengers H, Djudjaj S, von Stillfried S, H?lscher DL, Pieters TT, van Zuilen AD, Bemelman FJ, Nurmohamed AS, Naesens M, Roelofs JJTH, Florquin S, Floege J, Nguyen TQ, Kather JN, Boor P. Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study. Lancet Digit Health. 2022 01; 4(1):e18-e26.

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Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V. One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. J Am Chem Soc. 2021 08 11; 143(31):12315-12327.

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Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reprod Biomed Online. 2021 Oct; 43(4):614-626.

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Kulak O, Drobysheva A, Wick N, Arvisais-Anhalt S, Germans SK, Timmons CF, Park JY. Smart Glasses as a Surgical Pathology Grossing Tool. Arch Pathol Lab Med. 2021 04 01; 145(4):457-460.

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Njie-Carr VPS, Zhu S, Williams GC, Corless IB, Himelhoch S. Evaluation of a technology-enhanced intervention for older women with HIV infection: a proof of concept study. AIDS Care. 2021 08; 33(8):983-992.

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