Src Homology 2 Domain-Containing, Transforming Protein 1
"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
| Descriptor ID |
D000071425
|
| MeSH Number(s) |
D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
|
| Concept/Terms |
Src Homology 2 Domain-Containing, Transforming Protein 1- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain Containing, Transforming Protein 1
- ShcA Protein
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".
This graph shows the total number of publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in this website by year, and whether "Src Homology 2 Domain-Containing, Transforming Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in Profiles.
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Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A. The p52 isoform of SHC1 is a key driver of breast cancer initiation. Breast Cancer Res. 2019 06 15; 21(1):74.
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Capri M, Salvioli S, Sevini F, Valensin S, Celani L, Monti D, Pawelec G, De Benedictis G, Gonos ES, Franceschi C. The genetics of human longevity. Ann N Y Acad Sci. 2006 May; 1067:252-63.
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Morrione A, Romano G, Navarro M, Reiss K, Valentinis B, Dews M, Eves E, Rosner MR, Baserga R. Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells. Cancer Res. 2000 Apr 15; 60(8):2263-72.
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Aplin AE, Short SM, Juliano RL. Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains. J Biol Chem. 1999 Oct 29; 274(44):31223-8.
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Zhu W, Eicher A, Leber B, Andrews DW. At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes. Oncogene. 1998 Aug 06; 17(5):565-76.
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Valentinis B, Morrione A, Taylor SJ, Baserga R. Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Mol Cell Biol. 1997 Jul; 17(7):3744-54.