"Nogo Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
| Descriptor ID |
D000070798
|
| MeSH Number(s) |
D12.776.543.620.738 D12.776.631.580.738
|
| Concept/Terms |
Nogo Proteins- Nogo Proteins
- Nogo Protein
- Reticulon-4 Protein
- Reticulon 4 Protein
Nogo-A Protein- Nogo-A Protein
- Nogo A Protein
- NI-250 Protein
- NI 250 Protein
- NI-220 Protein
- NI 220 Protein
Nogo-B Protein- Nogo-B Protein
- Nogo B Protein
- Reticulon 4-B Protein
- Reticulon 4 B Protein
|
Below are MeSH descriptors whose meaning is more general than "Nogo Proteins".
Below are MeSH descriptors whose meaning is more specific than "Nogo Proteins".
This graph shows the total number of publications written about "Nogo Proteins" by people in this website by year, and whether "Nogo Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
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Below are the most recent publications written about "Nogo Proteins" by people in Profiles.
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Bullard TA, Protack TL, Aguilar F, Bagwe S, Massey HT, Blaxall BC. Identification of Nogo as a novel indicator of heart failure. Physiol Genomics. 2008 Jan 17; 32(2):182-9.
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Venkatesh K, Chivatakarn O, Sheu SS, Giger RJ. Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol. 2007 May 07; 177(3):393-9.
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Fournier AE, Gould GC, Liu BP, Strittmatter SM. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J Neurosci. 2002 Oct 15; 22(20):8876-83.