"Uncoupling Protein 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial uncoupling protein that is expressed in heart and skeletal muscle tissues. It functions to regulate tissue respiration, energy balance, and THERMOGENESIS. Mutations in the UCP3 gene are associated with OBESITY.
| Descriptor ID |
D000071247
|
| MeSH Number(s) |
D12.776.157.530.937.598.875 D12.776.543.585.475.688.875 D12.776.543.585.937.696.875 D12.776.575.750.688.875
|
| Concept/Terms |
Uncoupling Protein 3- Uncoupling Protein 3
- Uncoupling Protein-3
- Solute Carrier Family 25 Member 9
- UCP3 Protein
- SLC25A9 Protein
- Mitochondrial Uncoupling Protein 3
|
Below are MeSH descriptors whose meaning is more general than "Uncoupling Protein 3".
Below are MeSH descriptors whose meaning is more specific than "Uncoupling Protein 3".
This graph shows the total number of publications written about "Uncoupling Protein 3" by people in this website by year, and whether "Uncoupling Protein 3" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Uncoupling Protein 3" by people in Profiles.
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Aguer C, Fiehn O, Seifert EL, B?zaire V, Meissen JK, Daniels A, Scott K, Renaud JM, Padilla M, Bickel DR, Dysart M, Adams SH, Harper ME. Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete ?-oxidation. FASEB J. 2013 Oct; 27(10):4213-25.
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Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle. 2013 Jan 01; 12(1):172-82.
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Estey C, Seifert EL, Aguer C, Moffat C, Harper ME. Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response. Exp Gerontol. 2012 May; 47(5):361-71.
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Mailloux RJ, Seifert EL, Bouillaud F, Aguer C, Collins S, Harper ME. Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem. 2011 Jun 17; 286(24):21865-75.
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Waldeck-Weiermair M, Duan X, Naghdi S, Khan MJ, Trenker M, Malli R, Graier WF. Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals. Cell Calcium. 2010 Nov; 48(5):288-301.
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Waldeck-Weiermair M, Malli R, Naghdi S, Trenker M, Kahn MJ, Graier WF. The contribution of UCP2 and UCP3 to mitochondrial Ca(2+) uptake is differentially determined by the source of supplied Ca(2+). Cell Calcium. 2010 May; 47(5):433-40.
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Bevilacqua L, Seifert EL, Estey C, Gerrits MF, Harper ME. Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice. Biochim Biophys Acta. 2010 Aug; 1797(8):1389-97.
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Watanabe H, Bohensky J, Freeman T, Srinivas V, Shapiro IM. Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. J Cell Physiol. 2008 Aug; 216(2):419-25.
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Seifert EL, B?zaire V, Estey C, Harper ME. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem. 2008 Sep 12; 283(37):25124-25131.
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Costford SR, Seifert EL, B?zaire V, F Gerrits M, Bevilacqua L, Gowing A, Harper ME. The energetic implications of uncoupling protein-3 in skeletal muscle. Appl Physiol Nutr Metab. 2007 Oct; 32(5):884-94.