Epithelial Cell Adhesion Molecule

"Epithelial Cell Adhesion Molecule" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cell adhesion molecule that is expressed on the membranes of nearly all EPITHELIAL CELLS, especially at the junctions between intestinal epithelial cells and intraepithelial LYMPHOCYTES. It also is expressed on the surface of ADENOCARCINOMA and epithelial tumor cells. It may function in the MUCOSA through homophilic interactions to provide a barrier against infection. It also regulates the proliferation and differentiation of EMBRYONIC STEM CELLS.

Descriptor ID	D000071858
MeSH Number(s)	D12.776.395.550.200.263 D12.776.543.550.200.263 D23.050.285.357 D23.050.301.350.263
Concept/Terms	Epithelial Cell Adhesion Molecule Epithelial Cell Adhesion Molecule CD326 Protein Antigen, CD326 CD326 Antigen ESA Antigen Antigen, ESA EpCAM GA733 Antigen Antigen, GA733 GA733 Tumor-Associated Antigen GA733 Tumor Associated Antigen Tumor-Associated Antigen, GA733 Tacstd1 Protein Epithelial Specific Antigen Antigen, Epithelial Specific Ep-CAM Tumor-Associated Antigen GA733 GA733, Tumor-Associated Antigen Tumor Associated Antigen GA733 GA 733 Tumor-Associated Antigen GA 733 Tumor Associated Antigen

Below are MeSH descriptors whose meaning is more general than "Epithelial Cell Adhesion Molecule".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Cell Adhesion Molecules [D12.776.395.550.200]
Epithelial Cell Adhesion Molecule [D12.776.395.550.200.263]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Cell Adhesion Molecules [D12.776.543.550.200]
Epithelial Cell Adhesion Molecule [D12.776.543.550.200.263]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Neoplasm [D23.050.285]
Epithelial Cell Adhesion Molecule [D23.050.285.357]
Antigens, Surface [D23.050.301]
Cell Adhesion Molecules [D23.050.301.350]
Epithelial Cell Adhesion Molecule [D23.050.301.350.263]

Below are MeSH descriptors whose meaning is related to "Epithelial Cell Adhesion Molecule".

Below are MeSH descriptors whose meaning is more specific than "Epithelial Cell Adhesion Molecule".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epithelial Cell Adhesion Molecule" by people in this website by year, and whether "Epithelial Cell Adhesion Molecule" was a major or minor topic of these publications.

Bar chart showing 16 publications over 12 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2003	0	1	1
2007	0	1	1
2009	0	1	1
2010	0	1	1
2012	0	3	3
2013	0	1	1
2014	0	1	1
2015	0	1	1
2016	1	1	2
2019	1	1	2

Below are the most recent publications written about "Epithelial Cell Adhesion Molecule" by people in Profiles.

Beck TN, Boumber YA, Aggarwal C, Pei J, Thrash-Bingham C, Fittipaldi P, Vlasenkova R, Rao C, Borghaei H, Cristofanilli M, Mehra R, Serebriiskii I, Alpaugh RK. Circulating tumor cell and cell-free RNA capture and expression analysis identify platelet-associated genes in metastatic lung cancer. BMC Cancer. 2019 Jun 19; 19(1):603.

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Takai A, Dang H, Oishi N, Khatib S, Martin SP, Dominguez DA, Luo J, Bagni R, Wu X, Powell K, Ye QH, Jia HL, Qin LX, Chen J, Mitchell GA, Luo X, Thorgeirsson SS, Wang XW. Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma. Cancer Res. 2019 05 01; 79(9):2379-2391.

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Thamm DH, Hayes DF, Meuten T, Laver T, Thomas DG. Epithelial Cell Adhesion Molecule Expression in Canine Tumours. J Comp Pathol. 2016 Nov; 155(4):299-304.

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Takai A, Fako V, Dang H, Forgues M, Yu Z, Budhu A, Wang XW. Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma. Sci Rep. 2016 Feb 16; 6:21174.

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Kelley RK, Magbanua MJ, Butler TM, Collisson EA, Hwang J, Sidiropoulos N, Evason K, McWhirter RM, Hameed B, Wayne EM, Yao FY, Venook AP, Park JW. Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls. BMC Cancer. 2015 Mar 31; 15:206.

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Adams DL, Stefansson S, Haudenschild C, Martin SS, Charpentier M, Chumsri S, Cristofanilli M, Tang CM, Alpaugh RK. Cytometric characterization of circulating tumor cells captured by microfiltration and their correlation to the CellSearch(?) CTC test. Cytometry A. 2015 Feb; 87(2):137-44.

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Connor JP, Cristea MC, Lewis NL, Lewis LD, Komarnitsky PB, Mattiacci MR, Felder M, Stewart S, Harter J, Henslee-Downey J, Kramer D, Neugebauer R, Stupp R. A phase 1b study of humanized KS-interleukin-2 (huKS-IL2) immunocytokine with cyclophosphamide in patients with EpCAM-positive advanced solid tumors. BMC Cancer. 2013 Jan 15; 13:20.

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Trerotola M, Li J, Alberti S, Languino LR. Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the ?1 integrin-RACK1 axis. J Cell Physiol. 2012 Nov; 227(11):3670-7.

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Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani SA, Esteva FJ, Cristofanilli M, Reuben JM. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Mol Cancer Ther. 2012 Nov; 11(11):2526-34.

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Gaiser MR, L?mmermann T, Feng X, Igyarto BZ, Kaplan DH, Tessarollo L, Germain RN, Udey MC. Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):E889-97.

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