Promyelocytic Leukemia Zinc Finger Protein
"Promyelocytic Leukemia Zinc Finger Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Krupple-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
| Descriptor ID |
D000075722
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| MeSH Number(s) |
D12.776.260.522.625 D12.776.930.375.625
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Zinc Finger Protein".
Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Zinc Finger Protein".
This graph shows the total number of publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in this website by year, and whether "Promyelocytic Leukemia Zinc Finger Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in Profiles.
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Zhang B, Jiao A, Dai M, Wiest DL, Zhuang Y. Id3 Restricts ?d NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol. 2018 09 01; 201(5):1452-1459.
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Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL. A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol. 2013 Mar 01; 190(5):2121-8.
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Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16264-9.