"Droxidopa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
| Descriptor ID |
D015103
|
| MeSH Number(s) |
D02.092.211.215.311.560.220 D02.092.311.830.220 D12.125.154.800.875
|
| Concept/Terms |
Droxidopa- Droxidopa
- threo-DOPS
- threo DOPS
- 3,4-threo-DOPS
- 3,4 threo DOPS
- DL-threo-3,4-Dihydroxyphenylserine
- DL threo 3,4 Dihydroxyphenylserine
|
Below are MeSH descriptors whose meaning is more general than "Droxidopa".
Below are MeSH descriptors whose meaning is more specific than "Droxidopa".
This graph shows the total number of publications written about "Droxidopa" by people in this website by year, and whether "Droxidopa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 4 | 0 | 4 |
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Below are the most recent publications written about "Droxidopa" by people in Profiles.
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Gupta F, Kremens D, Vernino S, Karabin B. Managing neurogenic orthostatic hypotension in a patient presenting with pure autonomic failure who later developed Parkinson disease. Clin Auton Res. 2017 07; 27(Suppl 1):9-11.
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Kremens D, Lew M, Claassen D, Goodman BP. Adding droxidopa to fludrocortisone or midodrine in a patient with neurogenic orthostatic hypotension and Parkinson disease. Clin Auton Res. 2017 07; 27(Suppl 1):29-31.
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Lew M, Kremens D. Differential diagnosis of suspected neurogenic orthostatic hypotension in a patient with Parkinson disease. Clin Auton Res. 2017 07; 27(Suppl 1):5-7.
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Vernino S, Lew M, Kremens D. Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. Clin Auton Res. 2017 07; 27(Suppl 1):35-37.