Gene Rearrangement, B-Lymphocyte, Light Chain
"Gene Rearrangement, B-Lymphocyte, Light Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.
| Descriptor ID |
D015328
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| MeSH Number(s) |
G05.344.401.601 G12.500.274.601
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| Concept/Terms |
Gene Rearrangement, B-Lymphocyte, Light Chain- Gene Rearrangement, B-Lymphocyte, Light Chain
- B-Cell Light Chain Gene Rearrangement
- B-Lymphocyte Light Chain Gene Rearrangement
- B Cell Light Chain Gene Rearrangement
- B Lymphocyte Light Chain Gene Rearrangement
|
Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte, Light Chain".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte, Light Chain".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in this website by year, and whether "Gene Rearrangement, B-Lymphocyte, Light Chain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in Profiles.
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Alley CL, Wang E, Dunphy CH, Gong JZ, Lu CM, Boswell EL, Burchette J, Lagoo AS. Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature. Arch Pathol Lab Med. 2013 Apr; 137(4):503-17.
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Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol. 2008 May 01; 180(9):6094-106.
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Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR. Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors. J Autoimmun. 2007 Dec; 29(4):236-45.
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Hardy RR, Shinton SA. Characterization of B lymphopoiesis in mouse bone marrow and spleen. Methods Mol Biol. 2004; 271:1-24.
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Ruetsch NR, Bosma GC, Bosma MJ. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med. 2000 Jun 05; 191(11):1933-43.
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Raschke EE, Albert T, Eick D. Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II. J Immunol. 1999 Oct 15; 163(8):4375-82.
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Bosma GC, Chang Y, Karasuyama H, Bosma MJ. Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11952-7.
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Chang Y, Bosma MJ. Effect of different Ig transgenes on B cell differentiation in scid mice. Int Immunol. 1997 Mar; 9(3):373-80.
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Reichman-Fried M, Bosma MJ, Hardy RR. B-lineage cells in mu-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement. Int Immunol. 1993 Mar; 5(3):303-10.