Chloramphenicol O-Acetyltransferase
"Chloramphenicol O-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
| Descriptor ID |
D015500
|
| MeSH Number(s) |
D08.811.913.050.134.170
|
| Concept/Terms |
Chloramphenicol O-Acetyltransferase- Chloramphenicol O-Acetyltransferase
- Chloramphenicol O Acetyltransferase
- O-Acetyltransferase, Chloramphenicol
- Chloramphenicol Transacetylase
- Transacetylase, Chloramphenicol
- CAT Enzyme
- Enzyme, CAT
- Chloramphenicol Acetyltransferase
- Acetyltransferase, Chloramphenicol
|
Below are MeSH descriptors whose meaning is more general than "Chloramphenicol O-Acetyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Chloramphenicol O-Acetyltransferase".
This graph shows the total number of publications written about "Chloramphenicol O-Acetyltransferase" by people in this website by year, and whether "Chloramphenicol O-Acetyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 3 | 3 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chloramphenicol O-Acetyltransferase" by people in Profiles.
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Natori Y, Tagami K, Murakami K, Yoshida S, Tanigawa O, Moh Y, Masuda K, Wada T, Suzuki S, Nanamiya H, Tozawa Y, Kawamura F. Transcription activity of individual rrn operons in Bacillus subtilis mutants deficient in (p)ppGpp synthetase genes, relA, yjbM, and ywaC. J Bacteriol. 2009 Jul; 191(14):4555-61.
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Kaplan MH, Zong RT, Herrscher RF, Scheuermann RH, Tucker PW. Transcriptional activation by a matrix associating region-binding protein. contextual requirements for the function of bright. J Biol Chem. 2001 Jun 15; 276(24):21325-30.
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Laine P, Reunanen N, Ravanti L, Foschi M, Santra M, Iozzo RV, K?h?ri VM. Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts. Biochem J. 2000 Jul 01; 349(Pt 1):19-25.
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Manzella L, Gualdi R, Perrotti D, Nicolaides NC, Girlando G, Giuffrida MA, Messina A, Calabretta B. The interferon regulatory factors 1 and 2 bind to a segment of the human c-myb first intron: possible role in the regulation of c-myb expression. Exp Cell Res. 2000 Apr 10; 256(1):248-56.
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Nadkarni V, Gabbay KH, Bohren KM, Sheikh-Hamad D. Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. J Biol Chem. 1999 Jul 16; 274(29):20185-90.
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Grassilli E, Salomoni P, Perrotti D, Franceschi C, Calabretta B. Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction. Cancer Res. 1999 May 15; 59(10):2451-6.
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Aho S, Rothenberger K, Tan EM, Ryoo YW, Cho BH, McLean WH, Uitto J. Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements. Genomics. 1999 Mar 01; 56(2):160-8.
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Frenkel B, Capparelli C, Van Auken M, Baran D, Bryan J, Stein JL, Stein GS, Lian JB. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology. 1997 May; 138(5):2109-16.
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Salomoni P, Perrotti D, Martinez R, Franceschi C, Calabretta B. Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3296-301.
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Hitraya EG, Jimenez SA, Ludwicka A, Silver RM, Varga J. Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. Int J Biochem Cell Biol. 1997 Jan; 29(1):135-41.