Polymerase Chain Reaction

"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Descriptor ID	D016133
MeSH Number(s)	E05.393.620.500
Concept/Terms	Polymerase Chain Reaction Polymerase Chain Reaction Polymerase Chain Reactions Reaction, Polymerase Chain Reactions, Polymerase Chain PCR Inverse PCR Inverse PCR PCR, Inverse Inverse Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested Polymerase Chain Reaction Nested PCR PCR, Nested Anchored PCR Anchored PCR PCR, Anchored Anchored Polymerase Chain Reaction

Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Amplification Techniques [E05.393.620]
Polymerase Chain Reaction [E05.393.620.500]

Below are MeSH descriptors whose meaning is related to "Polymerase Chain Reaction".

Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.

Bar chart showing 435 publications over 29 distinct years, with a maximum of 46 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	28	30
1997	5	41	46
1998	0	25	25
1999	3	21	24
2000	2	27	29
2001	1	19	20
2002	0	17	17
2003	2	24	26
2004	0	22	22
2005	4	17	21
2006	2	18	20
2007	2	17	19
2008	1	18	19
2009	0	15	15
2010	1	12	13
2011	0	11	11
2012	1	11	12
2013	0	8	8
2014	1	10	11
2015	3	9	12
2016	1	10	11
2017	2	4	6
2018	0	4	4
2019	2	3	5
2020	0	2	2
2021	1	1	2
2022	0	1	1
2023	0	2	2
2024	1	1	2

Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.

Vitello DJ, Shah D, Wells A, Masnyk L, Cox M, Janczewski LM, Abad J, Dawravoo K, D'Souza A, Suh G, Bayer R, Cristofanilli M, Bentrem D, Liu Y, Zhang H, Santana-Santos L, Jennings LJ, Zhang Q, Chawla A. Mutant KRAS in Circulating Tumor DNA as a Biomarker in Localized Pancreatic Cancer Patients Treated With Neoadjuvant Chemotherapy. Ann Surg. 2026 07 01; 284(1):99-107.

View in: PubMed
Chau VQ, Hinkle JW, Wu CY, Pakravan P, Volante V, Sengillo JD, Staropoli PC, Miller D, Yannuzzi NA, Albini TA. OUTCOMES OF INFECTIOUS PANUVEITIS ASSOCIATED WITH SIMULTANEOUS MULTI-POSITIVE OCULAR FLUID POLYMERASE CHAIN REACTION. Retina. 2024 05 01; 44(5):909-915.

View in: PubMed
Fernandez-Tejero N, Sanchez AN, Ghemrawi M, Bilodeau C, Etim S, Duncan G, Cochran M, McCord B. A study of the potential application of digital PCR in the detection of fecal contamination of strawberries using Bacteroides markers. J Microbiol Methods. 2023 09; 212:106811.

View in: PubMed
Mudhar HS, Milman T, Stevenson S, Watson M, Kim J, Magan T, Salvi SM, Harley U, Lally SE, Shields CL. PRAME expression by immunohistochemistry and reverse transcription quantitative PCR in conjunctival melanocytic lesions-a comprehensive clinicopathologic study of 202 cases and correlation of cytogenetics with PRAME expression in challenging conjunctival melanocytic lesions. Hum Pathol. 2023 04; 134:1-18.

View in: PubMed
Hamilton TW, Ingelsrud LH, Gutman M, Shearman AD, Gromov K, Alvand A, Troelsen A, Parvizi J, Price AJ. Preoperative Severe Acute Respiratory Syndrome Coronavirus 2?Polymerase Chain Reaction Test at Between 48 and 72?Hours Preoperatively is Safe for Patients Undergoing Primary and Revision Hip and Knee Arthroplasty: A Multicentre International Study. J Arthroplasty. 2022 07; 37(7):1253-1259.

View in: PubMed
Boelens D, Fogliatto Mariot R, Ghemrawi M, Kloosterman AD, McCord BR. The development of miniSTRs as a method for high-speed direct PCR. Electrophoresis. 2021 07; 42(12-13):1352-1361.

View in: PubMed
Stabley DL, Holbrook J, Scavina M, Crawford TO, Swoboda KJ, Robbins KM, Butchbach MER. Detection of SMN1 to SMN2 gene conversion events and partial SMN1 gene deletions using array digital PCR. Neurogenetics. 2021 03; 22(1):53-64.

View in: PubMed
Righi A, Sbaraglia M, Gambarotti M, Gibertoni D, Rovira MP, Benini S, Errani C, Brenca M, Maestro R, Dei Tos AP. Primary Vascular Tumors of Bone: A Monoinstitutional Morphologic and Molecular Analysis of 427 Cases With Emphasis on Epithelioid Variants. Am J Surg Pathol. 2020 09; 44(9):1192-1203.

View in: PubMed
Lee CS, Hong B, Kasi SK, Aderman C, Talcott KE, Adam MK, Yue B, Akileswaran L, Nakamichi K, Wu Y, Rezaei KA, Olmos de Koo LC, Chee YE, Lee AY, Garg SJ, Van Gelder RN. Prognostic Utility of Whole-Genome Sequencing and Polymerase Chain Reaction Tests of Ocular Fluids in Postprocedural Endophthalmitis. Am J Ophthalmol. 2020 09; 217:325-334.

View in: PubMed
Pearson MD, Nguyen L, Zhao Y, McKenna WL, Morin TJ, Dunbar WB. Fast and accurate quantification of insertion-site specific transgene levels from raw seed samples using solid-state nanopore technology. PLoS One. 2019; 14(12):e0226719.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement