Receptors, N-Methyl-D-Aspartate

"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Descriptor ID	D016194
MeSH Number(s)	D12.776.157.530.400.400.500.500 D12.776.543.550.450.500.200.500 D12.776.543.585.400.500.200.500 D12.776.543.750.720.200.450.400.500
Concept/Terms	Receptors, N-Methyl-D-Aspartate Receptors, N-Methyl-D-Aspartate Receptors, N Methyl D Aspartate N-Methyl-D-Aspartate Receptors N Methyl D Aspartate Receptors NMDA Receptors Receptors, N-Methylaspartate Receptors, N Methylaspartate Receptors, NMDA NMDA Receptor-Ionophore Complex NMDA Receptor Ionophore Complex N-Methylaspartate Receptors N Methylaspartate Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Amino Acid [D12.776.543.750.720.200]
Receptors, Glutamate [D12.776.543.750.720.200.450]
Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]

Below are MeSH descriptors whose meaning is related to "Receptors, N-Methyl-D-Aspartate".

Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in this website by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publications.

Bar chart showing 34 publications over 21 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	2	2
1999	1	0	1
2000	1	0	1
2001	1	0	1
2002	1	2	3
2003	1	0	1
2004	0	1	1
2005	1	0	1
2007	0	1	1
2008	0	3	3
2009	1	0	1
2010	2	2	4
2011	1	0	1
2012	0	1	1
2015	0	1	1
2016	1	1	2
2017	2	0	2
2018	3	0	3
2019	1	1	2
2020	1	0	1
2022	1	0	1

Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.

Wilcox MR, Nigam A, Glasgow NG, Narangoda C, Phillips MB, Patel DS, Mesbahi-Vasey S, Turcu AL, V?zquez S, Kurnikova MG, Johnson JW. Inhibition of NMDA receptors through a membrane-to-channel path. Nat Commun. 2022 07 15; 13(1):4114.

View in: PubMed
Washburn HR, Xia NL, Zhou W, Mao YT, Dalva MB. Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility. Nat Commun. 2020 Jan 29; 11(1):570.

View in: PubMed
Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, Trotti D. Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis. Exp Neurol. 2019 06; 316:27-38.

View in: PubMed
Yue X, Xin Y, Chugani HT, Chugani DC, Zhang S. Automated production of a N-methyl-D-aspartate receptor radioligand [18F]GE179 for clinical use. Appl Radiat Isot. 2019 Jun; 148:246-252.

View in: PubMed
Yates JR, Prior NA, Chitwood MR, Day HA, Heidel JR, Hopkins SE, Muncie BT, Paradella-Bradley TA, Sestito AP, Vecchiola AN, Wells EE. Effects of GluN2B-selective antagonists on delay and probability discounting in male rats: Modulation by delay/probability presentation order. Exp Clin Psychopharmacol. 2018 Dec; 26(6):525-540.

View in: PubMed
Glasgow NG, Wilcox MR, Johnson JW. Effects of Mg2+ on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site. Neuropharmacology. 2018 07 15; 137:344-358.

View in: PubMed
Shin Y, Kokate R, Desai V, Bhushan A, Kaushal G. D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels. Drug Discov Ther. 2018; 12(3):142-153.

View in: PubMed
Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB. Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biol. 2017 Jul; 15(7):e2002457.

View in: PubMed
Simon DK, Wu C, Tilley BC, Lohmann K, Klein C, Payami H, Wills AM, Aminoff MJ, Bainbridge J, Dewey R, Hauser RA, Schaake S, Schneider JS, Sharma S, Singer C, Tanner CM, Truong D, Wei P, Wong PS, Yang T. Caffeine, creatine, GRIN2A and Parkinson's disease progression. J Neurol Sci. 2017 Apr 15; 375:355-359.

View in: PubMed
Schnitzer TJ, Torbey S, Herrmann K, Kaushal G, Yeasted R, Vania Apkarian A. A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain. Mol Pain. 2016; 12.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement