Macrophage-Activating Factors
"Macrophage-Activating Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
| Descriptor ID |
D016215
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| MeSH Number(s) |
D12.644.276.374.480.615 D12.776.467.374.480.615 D23.529.374.480.615
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Macrophage-Activating Factors".
Below are MeSH descriptors whose meaning is more specific than "Macrophage-Activating Factors".
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Below are the most recent publications written about "Macrophage-Activating Factors" by people in Profiles.
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Harris DT, Kozumbo WJ, Testa JE, Cerutti PA, Cerottini JC. Molecular mechanisms involved in T cell activation. III. The role of extracellular calcium in antigen-induced lymphokine production and interleukin 2-induced proliferation of cloned cytotoxic T lymphocytes. J Immunol. 1988 Feb 01; 140(3):921-7.
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Harris DT, Kozumbo WJ, Cerutti PA, Cerottini JC. Mechanism of cyclosporin A-induced immunosuppression. Cyclosporin A inhibits receptor-mediated and non-receptor-mediated lymphokine production as well as interleukin-2-induced proliferation in cloned T lymphocytes. Cell Immunol. 1987 Oct 01; 109(1):104-14.
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Kozumbo WJ, Harris DT, Gromkowski S, Cerottini JC, Cerutti PA. Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes. J Immunol. 1987 Jan 15; 138(2):606-12.
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Harris DT, Kozumbo WJ, Cerutti P, Cerottini JC. Molecular mechanisms involved in T cell activation. I. Evidence for independent signal-transducing pathways in lymphokine production vs proliferation in cloned cytotoxic T lymphocytes. J Immunol. 1987 Jan 15; 138(2):600-5.