Lymphoma, Large B-Cell, Diffuse

"Lymphoma, Large B-Cell, Diffuse" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Descriptor ID	D016403
MeSH Number(s)	C04.557.386.480.150.585 C15.604.515.569.480.150.585 C20.683.515.761.480.150.585
Concept/Terms	Lymphoma, Large B-Cell, Diffuse Lymphoma, Large B-Cell, Diffuse Diffuse, Large B-Cell, Lymphoma Histiocytic Lymphoma Histiocytic Lymphomas Lymphomas, Histiocytic Histiocytic Lymphoma, Diffuse Diffuse Histiocytic Lymphoma Diffuse Histiocytic Lymphomas Histiocytic Lymphomas, Diffuse Lymphoma, Diffuse Histiocytic Lymphomas, Diffuse Histiocytic Large Lymphoid Lymphoma, Diffuse Lymphoma, Large-Cell, Diffuse Lymphoma, Diffuse Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Histiocytic Lymphoma, Large Lymphoid, Diffuse Lymphoma, Histiocytic, Diffuse Lymphoma, Large Cell, Diffuse Diffuse Large-Cell Lymphoma Diffuse Large Cell Lymphoma Diffuse Large-Cell Lymphomas Large-Cell Lymphomas, Diffuse Lymphomas, Diffuse Large-Cell Large-Cell Lymphoma, Diffuse Large Cell Lymphoma, Diffuse

Below are MeSH descriptors whose meaning is more general than "Lymphoma, Large B-Cell, Diffuse".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Lymphoma [C04.557.386]
Lymphoma, Non-Hodgkin [C04.557.386.480]
Lymphoma, B-Cell [C04.557.386.480.150]
Lymphoma, Large B-Cell, Diffuse [C04.557.386.480.150.585]
Hemic and Lymphatic Diseases [C15]
Lymphatic Diseases [C15.604]
Lymphoproliferative Disorders [C15.604.515]
Lymphoma [C15.604.515.569]
Lymphoma, Non-Hodgkin [C15.604.515.569.480]
Lymphoma, B-Cell [C15.604.515.569.480.150]
Lymphoma, Large B-Cell, Diffuse [C15.604.515.569.480.150.585]
Immune System Diseases [C20]
Immunoproliferative Disorders [C20.683]
Lymphoproliferative Disorders [C20.683.515]
Lymphoma [C20.683.515.761]
Lymphoma, Non-Hodgkin [C20.683.515.761.480]
Lymphoma, B-Cell [C20.683.515.761.480.150]
Lymphoma, Large B-Cell, Diffuse [C20.683.515.761.480.150.585]

Below are MeSH descriptors whose meaning is related to "Lymphoma, Large B-Cell, Diffuse".

Below are MeSH descriptors whose meaning is more specific than "Lymphoma, Large B-Cell, Diffuse".

Lymphoma, Large B-Cell, Diffuse
Plasmablastic Lymphoma

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lymphoma, Large B-Cell, Diffuse" by people in this website by year, and whether "Lymphoma, Large B-Cell, Diffuse" was a major or minor topic of these publications.

Bar chart showing 92 publications over 29 distinct years, with a maximum of 8 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	1	1	2
1999	1	0	1
2000	3	1	4
2001	0	1	1
2002	1	1	2
2003	1	0	1
2004	1	1	2
2005	2	0	2
2006	4	0	4
2007	2	1	3
2008	3	0	3
2009	2	1	3
2010	2	2	4
2011	6	0	6
2012	1	0	1
2013	3	1	4
2014	5	1	6
2015	3	0	3
2016	4	1	5
2017	5	1	6
2018	1	0	1
2019	3	1	4
2020	3	0	3
2021	5	0	5
2022	8	0	8
2023	2	0	2
2024	4	0	4
2025	1	0	1

Below are the most recent publications written about "Lymphoma, Large B-Cell, Diffuse" by people in Profiles.

Kharfan-Dabaja MA, Mohty R, Easwar N, Johnston P, Iqbal M, Epperla N, Yared J, Ahmed N, Hamadani M, Beitinjaneh A, Narkhede M, Jagadeesh D, Ramakrishnan Geethakumari P, Dholaria B, Gergis U, Munoz J, Sandoval-Sus J, Locke FL, Fein J, Khurana A, Ayala E, Annunzio K, Rapoport AP, Lutfi F, Akhtar OS, Lekakis L, Mehta A, Oluwole OO, Logue J, Jain MD, Shore T, Durani U, Alhaj Moustafa M, McGuirk J, Lin Y, Yamshon S, Chavez JC. Chimeric antigen receptor T cell therapy in octogenarians with B cell lymphoma: a real-world US multicenter collaborative study. Bone Marrow Transplant. 2025 May; 60(5):632-639.

View in: PubMed
Rohan TZ, Suriano J, Tekmen V, Bhatti S, Talasila S, Joffe D, Holtmeyer C, Lee JB, Alpdogan O, Nikbakht N. Coexistence of large cell transformed mycosis fungoides and diffuse large B-cell lymphoma in one patient. J Cutan Pathol. 2024 Oct; 51(10):761-766.

View in: PubMed
Ahmed N, Sun F, Teigland C, Kilgore KM, Mohammadi I, Chambers J, Dieyi C, Feng C, Osborn J, Fu C, Gergis U. Chimeric Antigen Receptor T-Cell Access in Patients with Relapsed/Refractory Large B-Cell Lymphoma: Association of Access with Social Determinants of Health and Travel Time to Treatment Centers. Transplant Cell Ther. 2024 07; 30(7):714-725.

View in: PubMed
Uttam P, Gupta RK. Primary leptomeningeal CD30 positive diffuse large B cell lymphoma disguise as meningioma in a young adult: a case report. Int J Neurosci. 2025 Apr; 135(4):428-433.

View in: PubMed
Elgohary G, Yang Y, Gergis M, Yi D, Gergis U. Chimeric Antigen Receptor T - Cell Therapy for Large B-Cell Lymphoma Patients with Central Nervous System Involvement, a Systematic Review and Meta-analysis. Clin Lymphoma Myeloma Leuk. 2024 Apr; 24(4):e142-e151.

View in: PubMed
Seyedin R, Snider JT, Rajagopalan K, Wade SW, Gergis U. Chimeric antigen receptor T-cell treatment patterns in relapsed or refractory large B-cell lymphoma. Future Oncol. 2023 Jul; 19(22):1535-1547.

View in: PubMed
Fu JJ, Seth A, Ali N, Chandar A, Bains A. ALK-positive Large B-Cell Lymphoma With Multiple Epithelial Antigen Expression and PABPC1::ALK Fusion : A Novel Molecular Alteration. Am J Surg Pathol. 2023 08 01; 47(8):950-954.

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Yi D, Gergis M, Hsu J, Yang Y, Bi X, Aljurf M, Gergis U. Next-Generation Chimeric Antigen Receptor T-cells. Hematol Oncol Stem Cell Ther. 2022 Dec 15; 15(3):117-121.

View in: PubMed
Yi D, Gergis M, Elgohary G, Hsu J, Yang Y, Bi X, Gergis U. Chimeric Antigen Receptor T-cell Therapies in Lymphoma Patients with Central Nervous System Involvement. Hematol Oncol Stem Cell Ther. 2022 Dec 15; 15(3):66-72.

View in: PubMed
Alarcon Tomas A, Fein JA, Fried S, Flynn JR, Devlin SM, Fingrut WB, Anagnostou T, Alperovich A, Shah N, Fraint E, Lin RJ, Scordo M, Batlevi CL, Besser MJ, Dahi PB, Danylesko I, Giralt S, Imber BS, Jacoby E, Kedmi M, Nagler A, Palomba ML, Roshal M, Salles GA, Sauter C, Shem-Tov N, Shimoni A, Yahalom J, Yerushalmi R, Shah GL, Avigdor A, Perales MA, Shouval R. Outcomes of first therapy after CD19-CAR-T treatment failure in large B-cell lymphoma. Leukemia. 2023 01; 37(1):154-163.

View in: PubMed

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