NAD(P)H Dehydrogenase (Quinone)
"NAD(P)H Dehydrogenase (Quinone)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
| Descriptor ID |
D016660
|
| MeSH Number(s) |
D08.811.682.608.800.500
|
| Concept/Terms |
NAD(P)H Dehydrogenase (Quinone)- NAD(P)H Dehydrogenase (Quinone)
- Quinone Reductase
- Reductase, Quinone
- Phylloquinone Reductase
- Reductase, Phylloquinone
- DT Diaphorase
- Diaphorase, DT
- Menadione Reductase
- Reductase, Menadione
|
Below are MeSH descriptors whose meaning is more general than "NAD(P)H Dehydrogenase (Quinone)".
Below are MeSH descriptors whose meaning is more specific than "NAD(P)H Dehydrogenase (Quinone)".
This graph shows the total number of publications written about "NAD(P)H Dehydrogenase (Quinone)" by people in this website by year, and whether "NAD(P)H Dehydrogenase (Quinone)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "NAD(P)H Dehydrogenase (Quinone)" by people in Profiles.
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Kang HJ, Song HY, Ahmed MA, Guo Y, Zhang M, Chen C, Cristofanilli M, Horiuchi D, Vassilopoulos A. NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity. Free Radic Biol Med. 2018 10; 126:358-371.
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Jalal SI, Hanna N, Zon R, Masters GA, Borghaei H, Koneru K, Badve S, Prasad N, Somaiah N, Wu J, Yu Z, Einhorn L. Phase I Study of Amrubicin and Cyclophosphamide in Patients With Advanced Solid Organ Malignancies: HOG LUN 07-130. Am J Clin Oncol. 2017 Aug; 40(4):329-335.
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Bavisotto LM, Ellis DJ, Milner PG, Combs DL, Irwin I, Canafax DM. Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. J Clin Pharmacol. 2011 Apr; 51(4):561-74.
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Joseph P, Long DJ, Klein-Szanto AJ, Jaiswal AK. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Biochem Pharmacol. 2000 Jul 15; 60(2):207-14.
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Joseph P, Klein-Szanto AJ, Jaiswal AK. Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis. Br J Cancer. 1998 Aug; 78(3):312-20.
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Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ, Jaiswal AK. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998 Mar 27; 273(13):7382-9.
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Rushmore TH, Pickett CB. Xenobiotic responsive elements controlling inducible expression by planar aromatic compounds and phenolic antioxidants. Methods Enzymol. 1991; 206:409-20.