Clinical Trials, Phase I as Topic

"Clinical Trials, Phase I as Topic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.

Descriptor ID	D017321
MeSH Number(s)	E05.318.760.250.500.200 N05.715.360.775.088.500.200 N06.850.520.450.250.250.200
Concept/Terms	Clinical Trials, Phase I as Topic Clinical Trials, Phase I as Topic Clinical Trials, Phase I Phase 1 Clinical Trials Phase I Clinical Trials Clinical Trials, Phase 1 Evaluation Studies, FDA Phase I Evaluation Studies, FDA Phase I Evaluation Studies, FDA Phase 1 Microdosing Trials, Human Microdosing Trials, Human Human Microdosing Trial Microdosing Trial, Human Trial, Human Microdosing Trials, Human Microdosing Human Microdosing Trials Drug Evaluation, FDA Phase I as Topic Drug Evaluation, FDA Phase I as Topic Drug Evaluation, FDA Phase I Drug Evaluation, FDA Phase 1

Below are MeSH descriptors whose meaning is more general than "Clinical Trials, Phase I as Topic".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Epidemiologic Methods [E05.318]
Epidemiologic Study Characteristics [E05.318.760]
Clinical Studies as Topic [E05.318.760.250]
Clinical Trials as Topic [E05.318.760.250.500]
Clinical Trials, Phase I as Topic [E05.318.760.250.500.200]
Health Care [N]
Health Care Quality, Access, and Evaluation [N05]
Quality of Health Care [N05.715]
Health Care Evaluation Mechanisms [N05.715.360]
Epidemiologic Study Characteristics [N05.715.360.775]
Clinical Studies as Topic [N05.715.360.775.088]
Clinical Trials as Topic [N05.715.360.775.088.500]
Clinical Trials, Phase I as Topic [N05.715.360.775.088.500.200]
Environment and Public Health [N06]
Public Health [N06.850]
Epidemiologic Methods [N06.850.520]
Epidemiologic Study Characteristics [N06.850.520.450]
Clinical Studies as Topic [N06.850.520.450.250]
Clinical Trials as Topic [N06.850.520.450.250.250]
Clinical Trials, Phase I as Topic [N06.850.520.450.250.250.200]

Below are MeSH descriptors whose meaning is related to "Clinical Trials, Phase I as Topic".

Below are MeSH descriptors whose meaning is more specific than "Clinical Trials, Phase I as Topic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Clinical Trials, Phase I as Topic" by people in this website by year, and whether "Clinical Trials, Phase I as Topic" was a major or minor topic of these publications.

Bar chart showing 22 publications over 13 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2004	1	2	3
2008	0	1	1
2010	2	2	4
2012	0	1	1
2013	1	1	2
2014	2	1	3
2016	1	1	2
2020	0	1	1
2022	0	1	1
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Clinical Trials, Phase I as Topic" by people in Profiles.

Nicol? E, Gandini S, Giugliano F, Uliano J, D'Ecclesiis O, Morganti S, Ferraro E, Trapani D, Tarantino P, Zagami P, Boldrini L, Caramella I, Carnevale Schianca A, Cristofanilli M, Locatelli MA, Esposito A, Belli C, Minchella I, Criscitiello C, Marra A, Curigliano G. Effect of age on safety and efficacy of novel cancer drugs investigated in early-phase clinical trials. Eur J Cancer. 2024 Aug; 207:114181.

View in: PubMed
Ponzini FM, Schultz CW, Leiby BE, Cannaday S, Yeo T, Posey J, Bowne WB, Yeo C, Brody JR, Lavu H, Nevler A. Repurposing the FDA-approved anthelmintic pyrvinium pamoate for pancreatic cancer treatment: study protocol for a phase I clinical trial in early-stage pancreatic ductal adenocarcinoma. BMJ Open. 2023 10 17; 13(10):e073839.

View in: PubMed
Waguespack SG, Drilon A, Lin JJ, Brose MS, McDermott R, Almubarak M, Bauman J, Casanova M, Krishnamurthy A, Kummar S, Leyvraz S, Oh DY, Park K, Sohal D, Sherman E, Norenberg R, Silvertown JD, Brega N, Hong DS, Cabanillas ME. Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma. Eur J Endocrinol. 2022 Apr 29; 186(6):631-643.

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Pollack KE, Meneveau MO, Melssen MM, Lynch KT, Koeppel AF, Young SJ, Turner S, Kumar P, Sol-Church K, Mauldin IS, Slingluff CL. Incomplete Freund's adjuvant reduces arginase and enhances Th1 dominance, TLR signaling and CD40 ligand expression in the vaccine site microenvironment. J Immunother Cancer. 2020 04; 8(1).

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Al-Hallaq HA, Chmura S, Salama JK, Winter KA, Robinson CG, Pisansky TM, Borges V, Lowenstein JR, McNulty S, Galvin JM, Followill DS, Timmerman RD, White JR, Xiao Y, Matuszak MM. Rationale of technical requirements for NRG-BR001: The first NCI-sponsored trial of SBRT for the treatment of multiple metastases. Pract Radiat Oncol. 2016 Nov - Dec; 6(6):e291-e298.

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Kim H, Dan TD, Palmer JD, Leiby BE, Lawrence YR, Dicker AP. Quality and Reporting Accuracy of Phase 1 Drug Radiation Clinical Trials. JAMA Oncol. 2016 Mar; 2(3):390-1.

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Weber JS, Levit LA, Adamson PC, Bruinooge S, Burris HA, Carducci MA, Dicker AP, G?nen M, Keefe SM, Postow MA, Thompson MA, Waterhouse DM, Weiner SL, Schuchter LM. American Society of Clinical Oncology policy statement update: the critical role of phase I trials in cancer research and treatment. J Clin Oncol. 2015 Jan 20; 33(3):278-84.

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Blumenfeld P, Pfeffer RM, Symon Z, Den RB, Dicker AP, Raben D, Lawrence YR. The lag time in initiating clinical testing of new drugs in combination with radiation therapy, a significant barrier to progress? Br J Cancer. 2014 Sep 23; 111(7):1305-9.

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Sager PT, Kowey P. The thorough QT study: Is its demise on the horizon? Ann Noninvasive Electrocardiol. 2014 Jan; 19(1):1-3.

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Di WL, Mellerio JE, Bernadis C, Harper J, Abdul-Wahab A, Ghani S, Chan L, Martinez-Queipo M, Hara H, McNicol AM, Farzaneh F, McGrath J, Thrasher A, Qasim W. Phase I study protocol for ex vivo lentiviral gene therapy for the inherited skin disease, Netherton syndrome. Hum Gene Ther Clin Dev. 2013 Dec; 24(4):182-90.

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