Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor ID	D017398
MeSH Number(s)	G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
Concept/Terms	Alternative Splicing Alternative Splicing Alternative Splicings Splicings, Alternative Alternate Splicing Alternate Splicings Splicing, Alternate Splicings, Alternate RNA Splicing, Alternative Alternative RNA Splicing Alternative RNA Splicings RNA Splicings, Alternative Splicing, Alternative RNA Splicings, Alternative RNA Splicing, Alternative Nested Transcripts Nested Transcripts Nested Transcript Transcript, Nested Transcripts, Nested

Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Splicing [G02.111.760.700]
Alternative Splicing [G02.111.760.700.100]
Metabolism [G03]
RNA Processing, Post-Transcriptional [G03.839]
RNA Splicing [G03.839.700]
Alternative Splicing [G03.839.700.100]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
RNA Processing, Post-Transcriptional [G05.308.700]
RNA Splicing [G05.308.700.700]
Alternative Splicing [G05.308.700.700.100]

Below are MeSH descriptors whose meaning is related to "Alternative Splicing".

Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.

Bar chart showing 114 publications over 28 distinct years, with a maximum of 9 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	2	1	3
1998	0	4	4
1999	3	3	6
2000	2	2	4
2001	2	5	7
2002	7	1	8
2003	0	4	4
2004	2	1	3
2005	2	6	8
2006	4	5	9
2007	6	2	8
2008	1	5	6
2009	2	1	3
2010	4	1	5
2011	2	0	2
2012	0	2	2
2013	0	4	4
2014	3	2	5
2015	1	4	5
2016	0	2	2
2017	1	1	2
2019	4	4	8
2020	0	1	1
2021	0	1	1
2022	0	1	1
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Alternative Splicing" by people in Profiles.

Liu Z, Liao C, Zou L, Jin M, Shan Y, Quan Y, Yao H, Zhang L, Wang P, Liu Z, Wang N, Li A, Liu K, Tabashnik BE, Heckel DG, Wu K, Xiao Y. Retrotransposon-mediated disruption of a chitin synthase gene confers insect resistance to Bacillus thuringiensis Vip3Aa toxin. PLoS Biol. 2024 07; 22(7):e3002704.

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Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2221116120.

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Kanda S, Moulton E, Butchbach MER. Effects of Inhibitors of SLC9A-Type Sodium-Proton Exchangers on Survival Motor Neuron 2 (SMN2) mRNA Splicing and Expression. Mol Pharmacol. 2022 08; 102(2):92-105.

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Ramos-Ram?rez P, Tliba O. Glucocorticoid Receptor ? (GR?): Beyond Its Dominant-Negative Function. Int J Mol Sci. 2021 Mar 31; 22(7).

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Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH. MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. Nat Commun. 2020 05 12; 11(1):2369.

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Rondina MT, Voora D, Simon LM, Schwertz H, Harper JF, Lee O, Bhatlekar SC, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley ND, Kosaka Y, Weyrich AS, Bray PF, Rowley JW. Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circ Res. 2020 02 14; 126(4):501-516.

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Uitto J, Tirgan MH. Clinical Challenge and Call for Research on Keloid Disorder: Meeting Report from The 3rd International Keloid Research Foundation Symposium, Beijing 2019. J Invest Dermatol. 2020 03; 140(3):515-518.

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Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ. Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. Elife. 2019 09 03; 8.

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Vahidnezhad H, Youssefian L, Daneshpazhooh M, Mahmoudi H, Kariminejad A, Fischer J, Christiansen J, Schneider H, Guy A, Liu L, McGrath JA, Has C, Uitto J. Biallelic KRT5 mutations in autosomal recessive epidermolysis bullosa simplex, including a complete human keratin 5 "knock-out". Matrix Biol. 2019 10; 83:48-59.

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Y?ksel Z, Vogel F, Alhashem AM, Alanzi TSA, Tabarki B, Kampe K, Kandaswamy KK, Werber M, Bertoli-Avella AM, Beetz C, Rolfs A, Bauer P. A homozygous frameshift variant in an alternatively spliced exon of DLG5 causes hydrocephalus and renal dysplasia. Clin Genet. 2019 05; 95(5):631-633.

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