"Receptors, sigma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
| Descriptor ID |
D017480
|
| MeSH Number(s) |
D12.776.543.750.695.620.775 D12.776.543.750.720.600.610.775 D12.776.543.750.750.555.610.775
|
| Concept/Terms |
Receptors, sigma- Receptors, sigma
- sigma Receptors
- Receptors, sigma Opioid
- Opioid Receptors, sigma
- sigma Opioid Receptors
- Receptors, Opioid, sigma
- sigma Receptor
- Receptor, sigma
|
Below are MeSH descriptors whose meaning is more general than "Receptors, sigma".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Opioid [D12.776.543.750.695.620]
- Receptors, sigma [D12.776.543.750.695.620.775]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Opioid [D12.776.543.750.720.600.610]
- Receptors, sigma [D12.776.543.750.720.600.610.775]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Opioid [D12.776.543.750.750.555.610]
- Receptors, sigma [D12.776.543.750.750.555.610.775]
Below are MeSH descriptors whose meaning is more specific than "Receptors, sigma".
This graph shows the total number of publications written about "Receptors, sigma" by people in this website by year, and whether "Receptors, sigma" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 6 | 0 | 6 |
| 2018 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptors, sigma" by people in Profiles.
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Castagnino PA, Haas DA, Musante L, Tancler NA, Tran BV, Kean R, Steck AR, Martinez LA, Mostaghel EA, Hooper DC, Kim FJ. Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles. Cancer Biol Ther. 2025 12; 26(1):2455722.
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Cosentino G, Dichiara M, Ambrosio FA, Leotta CG, Costa G, Procopio F, Costanzo G, Raffa A, Artacho-Cord?n A, Ruiz-Cantero MC, Pasquinucci L, Marrazzo A, Pitari GM, Cobos EJ, Alcaro S, Amata E. Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds. Eur J Med Chem. 2025 Jan 05; 281:117037.
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Kim FJ, Pasternak GW. s1 Receptor ligand binding: an open-and-shut case. Nat Struct Mol Biol. 2018 11; 25(11):992-993.
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Maher CM, Thomas JD, Haas DA, Longen CG, Oyer HM, Tong JY, Kim FJ. Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1. Mol Cancer Res. 2018 02; 16(2):243-255.
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Kim FJ, Pasternak GW. Cloning the sigma2 receptor: Wandering 40 years to find an identity. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):6888-6890.
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Salvino JM, Srikanth YVV, Lou R, Oyer HM, Chen N, Kim FJ. Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer. Bioorg Med Chem Lett. 2017 05 15; 27(10):2216-2220.
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Thomas JD, Longen CG, Oyer HM, Chen N, Maher CM, Salvino JM, Kania B, Anderson KN, Ostrander WF, Knudsen KE, Kim FJ. Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer. Cancer Res. 2017 05 01; 77(9):2439-2452.
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Kim FJ. Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors. Handb Exp Pharmacol. 2017; 244:1-11.
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Kim FJ, Maher CM. Sigma1 Pharmacology in the Context of Cancer. Handb Exp Pharmacol. 2017; 244:237-308.
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Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K. Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. EMBO Mol Med. 2016 12; 8(12):1421-1437.