H(+)-K(+)-Exchanging ATPase
"H(+)-K(+)-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme isolated from the GASTRIC MUCOSA that catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions across the cell wall. This enzyme was formerly listed as EC 3.6.1.36.
| Descriptor ID |
D017506
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| MeSH Number(s) |
D08.811.277.040.025.314.625 D12.776.157.530.450.250.875.500.625 D12.776.157.530.813.625 D12.776.543.585.450.250.875.500.625 D12.776.543.585.813.625
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| Concept/Terms |
H(+)-K(+)-Exchanging ATPase- H(+)-K(+)-Exchanging ATPase
- Potassium Hydrogen ATPase
- ATPase, Potassium Hydrogen
- ATPase, Hydrogen, Potassium
- Hydrogen, Potassium ATPase
- ATPase Hydrogen, Potassium
- Adenosinetriphosphatase, Hydrogen, Potassium
- Hydrogen-Potassium-Exchanging ATPase
- ATPase, Hydrogen-Potassium-Exchanging
- Hydrogen Potassium Exchanging ATPase
- H(+)-K(+)-Transporting ATPase
- Adenosine Triphosphatase, Hydrogen, Potassium
- Hydrogen, Potassium, Adenosine Triphosphatase
- Gastric H(+) K(+) ATPase
- Hydrogen, Potassium, Adenosinetriphosphatase
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Below are MeSH descriptors whose meaning is more general than "H(+)-K(+)-Exchanging ATPase".
Below are MeSH descriptors whose meaning is more specific than "H(+)-K(+)-Exchanging ATPase".
This graph shows the total number of publications written about "H(+)-K(+)-Exchanging ATPase" by people in this website by year, and whether "H(+)-K(+)-Exchanging ATPase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "H(+)-K(+)-Exchanging ATPase" by people in Profiles.
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Gaur AH, McCarthy JS, Panetta JC, Dallas RH, Woodford J, Tang L, Smith AM, Stewart TB, Branum KC, Freeman BB, Patel ND, John E, Chalon S, Ost S, Heine RN, Richardson JL, Christensen R, Flynn PM, Van Gessel Y, Mitasev B, M?hrle JJ, Gusovsky F, Bebrevska L, Guy RK. Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. Lancet Infect Dis. 2020 08; 20(8):964-975.
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Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD. pH-dependent regulation of the a-subunit of H+-K+-ATPase (HKa2). Am J Physiol Renal Physiol. 2011 Sep; 301(3):F536-43.
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Reenstra WW, Crothers J, Forte JG. The conformation of H,K-ATPase determines the nucleoside triphosphate (NTP) selectivity for active proton transport. Biochemistry. 2007 Sep 04; 46(35):10145-52.
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Codina J, Liu J, Bleyer AJ, Penn RB, DuBose TD. Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase. J Am Soc Nephrol. 2006 Jul; 17(7):1833-40.
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Reenstra WW, Pinkus LM, Bailey J, Smith WL, Droppleman D, Sancilio LF, Forte JG. AHR-9294: a novel inhibitor of H,K-ATPase antagonizes gastric HCl secretion in vivo. J Pharmacol Exp Ther. 1992 May; 261(2):737-45.
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Crothers JM, Reenstra WW, Forte JG. Ontogeny of gastric H(+)-K(+)-ATPase in suckling rabbits. Am J Physiol. 1990 Dec; 259(6 Pt 1):G913-21.
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Reenstra WW, Forte JG. Isolation of H+,K(+)-ATPase-containing membranes from the gastric oxyntic cell. Methods Enzymol. 1990; 192:151-65.
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Reenstra WW, Bettencourt JD, Forte JG. Kinetic studies of the gastric H,K-ATPase. Evidence for simultaneous binding of ATP and inorganic phosphate. J Biol Chem. 1988 Dec 25; 263(36):19618-25.
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Reenstra WW, Bettencourt JD, Forte JG. Mechanisms of active Cl- secretion by frog gastric mucosa. Am J Physiol. 1987 Apr; 252(4 Pt 1):G543-7.
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Reenstra WW, Shortridge B, Forte JG. Inhibition of the gastric (H+ + K+)-ATPase by fenoctimine. Biochem Pharmacol. 1985 Jul 01; 34(13):2331-4.