Immunoglobulin Class Switching

"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

Descriptor ID	D017578
MeSH Number(s)	G05.344.401.501.450 G12.500.274.501.450
Concept/Terms	Immunoglobulin Class Switching Immunoglobulin Class Switching Class Switching, Immunoglobulin Class Switchings, Immunoglobulin Immunoglobulin Class Switchings Switching, Immunoglobulin Class Switchings, Immunoglobulin Class Class Switching Class Switchings Switching, Class Switchings, Class Isotype Switching Isotype Switchings Switching, Isotype Switchings, Isotype

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Class Switching".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Rearrangement [G05.344]
Gene Rearrangement, B-Lymphocyte [G05.344.401]
Gene Rearrangement, B-Lymphocyte, Heavy Chain [G05.344.401.501]
Immunoglobulin Class Switching [G05.344.401.501.450]
Immune System Phenomena [G12]
Immunogenetic Phenomena [G12.500]
Gene Rearrangement, B-Lymphocyte [G12.500.274]
Gene Rearrangement, B-Lymphocyte, Heavy Chain [G12.500.274.501]
Immunoglobulin Class Switching [G12.500.274.501.450]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Class Switching".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Class Switching".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in this website by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 2 publications in 2004 and 2006 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	0	1	1
2002	1	0	1
2004	1	1	2
2006	0	2	2
2007	1	1	2
2008	1	0	1
2015	0	1	1
2017	0	1	1
2018	1	0	1
2023	0	1	1

Below are the most recent publications written about "Immunoglobulin Class Switching" by people in Profiles.

Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SH, Bates P, Ramage H, Wilson PC, Hensley SE. IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2216521120.

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Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA. Parp3 promotes long-range end joining in murine cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10076-10081.

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Schell SL, Soni C, Fasnacht MJ, Domeier PP, Cooper TK, Rahman ZSM. Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers. J Immunol. 2017 12 15; 199(12):4001-4015.

View in: PubMed
Fahl SP, Harris B, Coffey F, Wiest DL. Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. J Immunol. 2015 Jan 01; 194(1):200-9.

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Giorgini A, Brown HJ, Lock HR, Nimmerjahn F, Ravetch JV, Verbeek JS, Sacks SH, Robson MG. Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies. J Immunol. 2008 Dec 15; 181(12):8745-52.

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Rahman ZS, Niu H, Perry D, Wakeland E, Manser T, Morel L. Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production. Genes Immun. 2007 Oct; 8(7):604-12.

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Kiefer K, Oshinsky J, Kim J, Nakajima PB, Bosma GC, Bosma MJ. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2843-8.

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Li J, Sai T, Berger M, Chao Q, Davidson D, Deshmukh G, Drozdowski B, Ebel W, Harley S, Henry M, Jacob S, Kline B, Lazo E, Rotella F, Routhier E, Rudolph K, Sage J, Simon P, Yao J, Zhou Y, Kavuru M, Bonfield T, Thomassen MJ, Sass PM, Nicolaides NC, Grasso L. Human antibodies for immunotherapy development generated via a human B cell hybridoma technology. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3557-62.

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Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98.

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Fukuyama H, Nimmerjahn F, Ravetch JV. The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells. Nat Immunol. 2005 Jan; 6(1):99-106.

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