"B7-1 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
| Descriptor ID |
D018122
|
| MeSH Number(s) |
D12.776.467.150.100 D12.776.543.095.100 D23.050.301.285.100 D23.529.168.100
|
| Concept/Terms |
B7-1 Antigen- B7-1 Antigen
- B7 1 Antigen
- CD80 Antigen
- CD80 Antigens
- B7-1 Ligand
- B7 1 Ligand
- Ligand, B7-1
- B7-1 Costimulatory Molecule
- B7 1 Costimulatory Molecule
- Costimulatory Molecule, B7-1
- Antigen, B7-1
- Antigen, B7 1
- B-Cell Activation Antigen
- B Cell Activation Antigen
- Antigens, CD80
|
Below are MeSH descriptors whose meaning is more general than "B7-1 Antigen".
Below are MeSH descriptors whose meaning is more specific than "B7-1 Antigen".
This graph shows the total number of publications written about "B7-1 Antigen" by people in this website by year, and whether "B7-1 Antigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 3 | 0 | 3 |
| 1999 | 2 | 1 | 3 |
| 2000 | 2 | 1 | 3 |
| 2001 | 1 | 2 | 3 |
| 2002 | 2 | 2 | 4 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 1 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2010 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "B7-1 Antigen" by people in Profiles.
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Bamboat ZM, Ocuin LM, Balachandran VP, Obaid H, Plitas G, DeMatteo RP. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest. 2010 Feb; 120(2):559-69.
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Crosby JR, Guha M, Tung D, Miller DA, Bender B, Condon TP, York-DeFalco C, Geary RS, Monia BP, Karras JG, Gregory SA. Inhaled CD86 antisense oligonucleotide suppresses pulmonary inflammation and airway hyper-responsiveness in allergic mice. J Pharmacol Exp Ther. 2007 Jun; 321(3):938-46.
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Cheng X, Zhao Z, Ventura E, Gran B, Shindler KS, Rostami A. The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma. J Neuroimmunol. 2007 Apr; 185(1-2):75-86.
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Radhakrishnan S, Nguyen LT, Ciric B, Van Keulen VP, Pease LR. B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 2007 Feb 01; 178(3):1426-32.
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Blocki FA, Radhakrishnan S, Van Keulen VP, Heckman KL, Ciric B, Howe CL, Rodriguez M, Kwon E, Pease LR. Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC. FASEB J. 2006 Nov; 20(13):2408-10.
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Wedgwood A, Pro B, Younes A. The lymphomas: molecular pathways and novel therapeutic targets. Curr Hematol Rep. 2005 Jul; 4(4):324-34.
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Dalakas MC. Autoimmune muscular pathologies. Neurol Sci. 2005 May; 26 Suppl 1:S7-8.
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Wakem P, Ramirez F, Zlotnick D, Gaspari AA. Heterogeneity of CD80 gene transcription by human keratinocytes to allergens and irritants: relevance to allergic contact dermatitis in vivo. J Appl Toxicol. 2004 Nov-Dec; 24(6):485-92.
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Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Res. 2004 Jul 15; 64(14):4965-72.
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Markovic-Plese S, Pinilla C, Martin R. The initiation of the autoimmune response in multiple sclerosis. Clin Neurol Neurosurg. 2004 Jun; 106(3):218-22.