"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D018741
|
| MeSH Number(s) |
G05.360.340.024.220.760 G05.360.340.024.745.725
|
| Concept/Terms |
Replication Origin- Replication Origin
- Origin, Replication
- Origins, Replication
- ori Region
- Region, ori
- Regions, ori
- ori Regions
- Origin of Replication
- Replication Origins
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Below are MeSH descriptors whose meaning is more general than "Replication Origin".
Below are MeSH descriptors whose meaning is more specific than "Replication Origin".
This graph shows the total number of publications written about "Replication Origin" by people in this website by year, and whether "Replication Origin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
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Below are the most recent publications written about "Replication Origin" by people in Profiles.
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Simmons DT, Gai D, Parsons R, Debes A, Roy R. Assembly of the replication initiation complex on SV40 origin DNA. Nucleic Acids Res. 2004; 32(3):1103-12.
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Jiao J, Simmons DT. Nonspecific double-stranded DNA binding activity of simian virus 40 large T antigen is involved in melting and unwinding of the origin. J Virol. 2003 Dec; 77(23):12720-8.
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Simmons DT, Roy R, Chen L, Gai D, Trowbridge PW. The activity of topoisomerase I is modulated by large T antigen during unwinding of the SV40 origin. J Biol Chem. 1998 Aug 07; 273(32):20390-6.
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Simmons DT, Trowbridge PW, Roy R. Topoisomerase I stimulates SV40 T antigen-mediated DNA replication and inhibits T antigen's ability to unwind DNA at nonorigin sites. Virology. 1998 Mar 15; 242(2):435-43.
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Rencic A, Gordon J, Otte J, Curtis M, Kovatich A, Zoltick P, Khalili K, Andrews D. Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7352-7.