Platelet Glycoprotein GPIIb-IIIa Complex
"Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
| Descriptor ID |
D019039
|
| MeSH Number(s) |
D12.776.395.550.625.785 D12.776.543.550.625.785 D12.776.543.750.705.408.460.700 D12.776.543.750.705.675.784
|
| Concept/Terms |
Platelet Glycoprotein GPIIb-IIIa Complex- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Glycoprotein GPIIb IIIa Complex
- Glycoproteins IIb-IIIa
- Glycoproteins IIb IIIa
- Integrin alpha-IIb beta-3
- Integrin alpha IIb beta 3
- beta-3, Integrin alpha-IIb
- Integrin alphaIIbbeta3
- alphaIIbbeta3, Integrin
- GPIIb-IIIa Receptors
- GPIIb IIIa Receptors
- Receptors, GPIIb-IIIa
|
Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIIb-IIIa Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIIb-IIIa Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 0 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 3 | 0 | 3 |
| 2000 | 3 | 0 | 3 |
| 2001 | 4 | 1 | 5 |
| 2002 | 2 | 1 | 3 |
| 2003 | 3 | 2 | 5 |
| 2004 | 2 | 1 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 2 | 1 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles.
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Nigam A, Manjuprasanna VN, Naik MU, Naik UP. Platelet spreading and clot retraction are regulated by 2 distinct aIIb?3 outside-in signaling pathways. J Pharmacol Exp Ther. 2025 01; 392(1):100012.
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Orzalkiewicz M, Hodson J, Kwok CS, Ludman PF, Giblett JP, George S, Doshi SN, Khan SQ, Kinnaird T, Hildick-Smith D, Townend JN, Mamas MA, Calvert PA. Comparison of Routine Versus Selective Glycoprotein IIb/IIIa Inhibitors Usage in Primary Percutaneous Coronary Intervention (from the British Cardiovascular Interventional Society). Am J Cardiol. 2019 08 01; 124(3):373-380.
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Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF. miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. J Thromb Haemost. 2019 03; 17(3):511-524.
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Olier I, Carr M, Curzen N, Ludman P, Baumbach A, Kinnaird T, de Belder MA, Hildick-Smith D, Sirker A, Kwok CS, Rashid M, Nolan J, Kontopantelis E, Mamas MA. Changes in Periprocedural Bleeding Complications Following Percutaneous Coronary Intervention in The United Kingdom Between 2006 and 2013 (from the British Cardiovascular Interventional Society). Am J Cardiol. 2018 09 15; 122(6):952-960.
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Naik MU, Naik TU, Summer R, Naik UP. Binding of CIB1 to the aIIb tail of aIIb?3 is required for FAK recruitment and activation in platelets. PLoS One. 2017; 12(5):e0176602.
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Sirker A, Mamas M, Robinson D, Anderson SG, Kinnaird T, Stables R, de Belder MA, Ludman P, Hildick-Smith D. Bivalirudin, glycoprotein inhibitor, and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom. Eur Heart J. 2016 Apr 21; 37(16):1312-20.
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Fanari Z, Weiss S, Weintraub WS. Cost Effectiveness of Antiplatelet and Antithrombotic Therapy in the Setting of Acute Coronary Syndrome: Current Perspective and Literature Review. Am J Cardiovasc Drugs. 2015 Dec; 15(6):415-27.
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Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2644-50.
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Naik UP. Bacteria exploit platelets. Blood. 2014 May 15; 123(20):3067-8.
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Naik MU, Caplan JL, Naik UP. Junctional adhesion molecule-A suppresses platelet integrin aIIb?3 signaling by recruiting Csk to the integrin-c-Src complex. Blood. 2014 Feb 27; 123(9):1393-402.