"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
| Descriptor ID |
D019328
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| MeSH Number(s) |
D02.886.030.676.620.125 D12.125.166.676.620.125
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Buthionine Sulfoximine".
Below are MeSH descriptors whose meaning is more specific than "Buthionine Sulfoximine".
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in this website by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Buthionine Sulfoximine" by people in Profiles.
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Lewis-Wambi JS, Kim HR, Wambi C, Patel R, Pyle JR, Klein-Szanto AJ, Jordan VC. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 2008; 10(6):R104.
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Teixeira CC, Rajpurohit R, Mansfield K, Nemelivsky YV, Shapiro IM. Maturation-dependent thiol loss increases chondrocyte susceptibility to apoptosis. J Bone Miner Res. 2003 Apr; 18(4):662-8.
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Vanella A, Di Giacomo C, Sorrenti V, Russo A, Castorina C, Campisi A, Renis M, Perez-Polo JR. Free radical scavenger depletion in post-ischemic reperfusion brain damage. Neurochem Res. 1993 Dec; 18(12):1337-40.
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O'Dwyer PJ, Hamilton TC, Young RC, LaCreta FP, Carp N, Tew KD, Padavic K, Comis RL, Ozols RF. Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. J Natl Cancer Inst. 1992 Feb 19; 84(4):264-7.