Tissue Inhibitor of Metalloproteinase-2
"Tissue Inhibitor of Metalloproteinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
| Descriptor ID |
D019716
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| MeSH Number(s) |
D12.776.645.875.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tissue Inhibitor of Metalloproteinase-2".
Below are MeSH descriptors whose meaning is more specific than "Tissue Inhibitor of Metalloproteinase-2".
This graph shows the total number of publications written about "Tissue Inhibitor of Metalloproteinase-2" by people in this website by year, and whether "Tissue Inhibitor of Metalloproteinase-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Tissue Inhibitor of Metalloproteinase-2" by people in Profiles.
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MacMillan YS, Mamas MA, Sun LY. IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery. Open Heart. 2022 06; 9(1).
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Durukan U, Agcaoglu O, Ozoran E, Karahan SN, Ozata I, Duzkoylu Y, Pasaoglu E, Aren A. The role of tissue inhibitor of metalloproteinases in the aetiology of inguinal and incisional hernias. Int Wound J. 2022 Oct; 19(6):1502-1508.
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Alam A, Jamil AK, Van Zyl JS, Medel-Martinez H, Bottiglieri T, Wasek B, Felius J, Lima B, Hall SA, Joseph SM. Urinary Cell-Cycle Arrest Biomarkers as Early Predictors of Acute Kidney Injury After Ventricular Assist Device Implantation or Cardiac Transplantation. J Cardiothorac Vasc Anesth. 2022 08; 36(8 Pt A):2303-2312.
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Jin L, Lim M, Zhao S, Sano Y, Simone BA, Savage JE, Wickstrom E, Camphausen K, Pestell RG, Simone NL. The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster. Breast Cancer Res Treat. 2014 Jul; 146(1):41-50.
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Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS. HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy. Eur J Neurosci. 2011 Dec; 34(12):2015-23.
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Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR. Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress. Pediatr Crit Care Med. 2007 Jan; 8(1):40-6.
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Miller TL, Touch SM, Shaffer TH. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: observations from an animal model. Pediatr Crit Care Med. 2006 Jan; 7(1):63-9.
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Miller TL, Touch SM, Singhaus CJ, Ramesh Babu PB, Chidekel A, Shaffer TH. Expression of matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2, in developing rabbit tracheae. Biol Neonate. 2006; 89(4):236-43.
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Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR. Effects of an intratracheally delivered anti-inflammatory protein (rhCC10) on physiological and lung structural indices in a juvenile model of acute lung injury. Biol Neonate. 2006; 89(3):159-70.
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Noujaim D, van Golen CM, van Golen KL, Grauman A, Feldman EL. N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells. Oncogene. 2002 Jul 04; 21(29):4549-57.