Sodium-Calcium Exchanger

"Sodium-Calcium Exchanger" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.

Descriptor ID	D019831
MeSH Number(s)	D12.776.157.530.450.162.442 D12.776.543.585.450.162.442
Concept/Terms	Sodium-Calcium Exchanger Sodium-Calcium Exchanger Exchanger, Sodium-Calcium Sodium Calcium Exchanger Sodium-Calcium Antiporter Antiporter, Sodium-Calcium Sodium Calcium Antiporter Calcium-Sodium Carrier Calcium Sodium Carrier Carrier, Calcium-Sodium Sodium-Calcium Carrier Carrier, Sodium-Calcium Sodium Calcium Carrier Na(+)-Ca(2+) Exchanger Na(+)-Ca(2+) Antiporter Calcium-Sodium Exchanger Calcium Sodium Exchanger Exchanger, Calcium-Sodium Ca(2+)-Na(+) Exchanger Calcium-Sodium Antiporter Antiporter, Calcium-Sodium Calcium Sodium Antiporter Ca(2+)-Na(+) Antiporter

Below are MeSH descriptors whose meaning is more general than "Sodium-Calcium Exchanger".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Antiporters [D12.776.157.530.450.162]
Sodium-Calcium Exchanger [D12.776.157.530.450.162.442]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Antiporters [D12.776.543.585.450.162]
Sodium-Calcium Exchanger [D12.776.543.585.450.162.442]

Below are MeSH descriptors whose meaning is related to "Sodium-Calcium Exchanger".

Below are MeSH descriptors whose meaning is more specific than "Sodium-Calcium Exchanger".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sodium-Calcium Exchanger" by people in this website by year, and whether "Sodium-Calcium Exchanger" was a major or minor topic of these publications.

Bar chart showing 16 publications over 11 distinct years, with a maximum of 3 publications in 2009 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2004	0	1	1
2008	1	0	1
2009	1	2	3
2010	1	0	1
2011	2	0	2
2012	1	0	1
2013	3	0	3
2015	1	0	1
2017	1	0	1
2019	1	0	1

Below are the most recent publications written about "Sodium-Calcium Exchanger" by people in Profiles.

Brenneman DE, Kinney WA, Ward SJ. Knockdown siRNA Targeting the Mitochondrial Sodium-Calcium Exchanger-1 Inhibits the Protective Effects of Two Cannabinoids Against Acute Paclitaxel Toxicity. J Mol Neurosci. 2019 Aug; 68(4):603-619.

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Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. J Biol Chem. 2017 07 07; 292(27):11388-11399.

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Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, Barwe SP. Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling. J Biol Chem. 2015 May 15; 290(20):12463-73.

View in: PubMed
Sharma V, He C, Sacca-Schaeffer J, Brzozowski E, Martin-Herranz DE, Mendelowitz Z, Fitzpatrick DA, O'Halloran DM. Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans. Genetics. 2013 Oct; 195(2):611-9.

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Cheung JY, Zhang XQ, Song J, Gao E, Chan TO, Rabinowitz JE, Koch WJ, Feldman AM, Wang J. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). Adv Exp Med Biol. 2013; 961:175-90.

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Wang J, Gao E, Chan TO, Zhang XQ, Song J, Shang X, Koch WJ, Feldman AM, Cheung JY. Induced overexpression of Na(+)/Ca(2+) exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction. J Card Fail. 2013 Jan; 19(1):60-70.

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Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW, Houser SR, Katus HA, Chen X, Koch WJ. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation. 2012 May 01; 125(17):2108-18.

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Song J, Gao E, Wang J, Zhang XQ, Chan TO, Koch WJ, Shang X, Joseph JI, Peterson BZ, Feldman AM, Cheung JY. Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. Am J Physiol Heart Circ Physiol. 2012 Feb 01; 302(3):H770-81.

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Zhang XQ, Wang J, Song J, Ji AM, Chan TO, Cheung JY. Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman. Am J Physiol Cell Physiol. 2011 Oct; 301(4):C833-40.

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Wang J, Gao E, Rabinowitz J, Song J, Zhang XQ, Koch WJ, Tucker AL, Chan TO, Feldman AM, Cheung JY. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol. 2011 Mar; 300(3):H859-68.

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