Mitogen-Activated Protein Kinase 1

"Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

Descriptor ID	D019950
MeSH Number(s)	D08.811.913.696.620.682.700.567.249.500 D12.644.360.450.169.500 D12.776.476.450.169.500
Concept/Terms	Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 1 Mitogen Activated Protein Kinase 1 p42 MAPK p42(Mitogen-Activated Protein Kinase) p42(Mapk) Kinase p42 MAP Kinase MAP Kinase, p42 MAPK2 Mitogen-Activated Protein Kinase MAPK2 Mitogen Activated Protein Kinase Extracellular Signal-Regulated Kinase 2 Extracellular Signal Regulated Kinase 2 Mitogen-Activated Protein Kinase 2 Mitogen Activated Protein Kinase 2 MAPK1 Mitogen-Activated Protein Kinase MAPK1 Mitogen Activated Protein Kinase p42(Mapk) MAP Kinase 2

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
Extracellular Signal-Regulated MAP Kinases [D08.811.913.696.620.682.700.567.249]
Mitogen-Activated Protein Kinase 1 [D08.811.913.696.620.682.700.567.249.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
Extracellular Signal-Regulated MAP Kinases [D12.644.360.450.169]
Mitogen-Activated Protein Kinase 1 [D12.644.360.450.169.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
Extracellular Signal-Regulated MAP Kinases [D12.776.476.450.169]
Mitogen-Activated Protein Kinase 1 [D12.776.476.450.169.500]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinase 1".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications.

Bar chart showing 42 publications over 22 distinct years, with a maximum of 5 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2000	2	1	3
2001	0	1	1
2002	1	0	1
2003	3	1	4
2004	0	2	2
2005	0	3	3
2006	2	3	5
2007	2	2	4
2008	0	1	1
2009	0	2	2
2010	1	2	3
2011	0	1	1
2012	0	1	1
2013	0	2	2
2015	1	0	1
2016	1	0	1
2017	0	2	2
2019	0	1	1
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles.

Shah SD, Nayak AP, Sharma P, Villalba DR, Addya S, Huang W, Shapiro P, Kane MA, Deshpande DA. Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice. Am J Respir Cell Mol Biol. 2023 01; 68(1):23-38.

View in: PubMed
Shupp AB, Neupane M, Agostini LC, Ning G, Brody JR, Bussard KM. Stromal-Derived Extracellular Vesicles Suppress Proliferation of Bone Metastatic Cancer Cells Mediated by ERK2. Mol Cancer Res. 2021 10; 19(10):1763-1777.

View in: PubMed
Zhang J, Koussih L, Shan L, Halayko AJ, Tliba O, Gounni AS. Glucocorticoids regulate pentraxin-3 expression in human airway smooth muscle cells. PLoS One. 2019; 14(8):e0220772.

View in: PubMed
Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L. Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci. 2017 Mar 09; 18(3).

View in: PubMed
Said AH, Hu S, Abutaleb A, Watkins T, Cheng K, Chahdi A, Kuppusamy P, Saxena N, Xie G, Raufman JP. Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J. 2017 02 20; 474(5):647-665.

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Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M. A PARP1-ERK2 synergism is required for the induction of LTP. Sci Rep. 2016 04 28; 6:24950.

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Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, Barwe SP. Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling. J Biol Chem. 2015 May 15; 290(20):12463-73.

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Cordovez JA, Capasso J, Lingao MD, Sadagopan KA, Spaeth GL, Wasserman BN, Levin AV. Ocular manifestations of 22q11.2 microduplication. Ophthalmology. 2014 Jan; 121(1):392-398.

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Danilo C, Gutierrez-Pajares JL, Mainieri MA, Mercier I, Lisanti MP, Frank PG. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. Breast Cancer Res. 2013; 15(5):R87.

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Barwe SP, Skay A, McSpadden R, Huynh TP, Langhans SA, Inge LJ, Rajasekaran AK. Na,K-ATPase ?-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells. J Cell Sci. 2012 Dec 01; 125(Pt 23):5711-20.

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