rac1 GTP-Binding Protein

"rac1 GTP-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASES. This enzyme was formerly listed as EC 3.6.1.47.

Descriptor ID	D020830
MeSH Number(s)	D08.811.277.040.330.300.400.700.100.500 D12.644.360.525.700.100.100 D12.776.157.325.515.700.100.100 D12.776.476.525.700.100.100
Concept/Terms	rac1 GTP-Binding Protein rac1 GTP-Binding Protein GTP-Binding Protein, rac1 rac1 GTP Binding Protein rac1 Protein TC-25 GTP-Binding Protein GTP-Binding Protein, TC-25 TC 25 GTP Binding Protein ras-Related C3 Botulinum Toxin Substrate 1 ras Related C3 Botulinum Toxin Substrate 1

Below are MeSH descriptors whose meaning is more general than "rac1 GTP-Binding Protein".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
rho GTP-Binding Proteins [D08.811.277.040.330.300.400.700]
rac GTP-Binding Proteins [D08.811.277.040.330.300.400.700.100]
rac1 GTP-Binding Protein [D08.811.277.040.330.300.400.700.100.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Monomeric GTP-Binding Proteins [D12.644.360.525]
rho GTP-Binding Proteins [D12.644.360.525.700]
rac GTP-Binding Proteins [D12.644.360.525.700.100]
rac1 GTP-Binding Protein [D12.644.360.525.700.100.100]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Monomeric GTP-Binding Proteins [D12.776.157.325.515]
rho GTP-Binding Proteins [D12.776.157.325.515.700]
rac GTP-Binding Proteins [D12.776.157.325.515.700.100]
rac1 GTP-Binding Protein [D12.776.157.325.515.700.100.100]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Monomeric GTP-Binding Proteins [D12.776.476.525]
rho GTP-Binding Proteins [D12.776.476.525.700]
rac GTP-Binding Proteins [D12.776.476.525.700.100]
rac1 GTP-Binding Protein [D12.776.476.525.700.100.100]

Below are MeSH descriptors whose meaning is related to "rac1 GTP-Binding Protein".

Below are MeSH descriptors whose meaning is more specific than "rac1 GTP-Binding Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rac1 GTP-Binding Protein" by people in this website by year, and whether "rac1 GTP-Binding Protein" was a major or minor topic of these publications.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 4 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	2	2
2005	1	0	1
2006	0	2	2
2007	0	1	1
2008	2	2	4
2010	2	1	3
2011	2	1	3
2013	2	1	3
2014	1	0	1
2015	1	1	2
2016	1	1	2
2017	0	1	1
2019	1	0	1
2020	1	0	1
2021	1	1	2
2025	1	0	1

Below are the most recent publications written about "rac1 GTP-Binding Protein" by people in Profiles.

Moazzeni S, Kyker-Snowman K, Cohen RI, Wang H, Li R, Shreiber DI, Zahn JD, Shi Z, Lin H. N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex. Sci Rep. 2025 02 04; 15(1):4296.

View in: PubMed
Duan X, Perveen R, Dandamudi A, Adili R, Johnson J, Funk K, Berryman M, Davis AK, Holinstat M, Zheng Y, Akbar H. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Sci Rep. 2021 06 23; 11(1):13170.

View in: PubMed
Nichols KE, Giraudo CG. RHOG: Rac1-ing up another HLH gene. Blood. 2021 04 15; 137(15):1990-1991.

View in: PubMed
Kikuchi M, Sekiya M, Hara N, Miyashita A, Kuwano R, Ikeuchi T, Iijima KM, Nakaya A. Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration. Hum Mol Genet. 2020 03 27; 29(5):817-833.

View in: PubMed
McBeath R, Edwards RW, O'Hara BJ, Maltenfort MG, Parks SM, Steplewski A, Osterman AL, Shapiro IM. Tendinosis develops from age- and oxygen tension-dependent modulation of Rac1 activity. Aging Cell. 2019 06; 18(3):e12934.

View in: PubMed
Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 08 01; 428(1):118-134.

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Hummler JK, Dapaah-Siakwan F, Vaidya R, Zambrano R, Luo S, Chen S, Kerr N, de Rivero Vaccari JP, Keane RW, Dietrich WD, Bancalari E, Young KC, Wu S. Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia. Neonatology. 2017; 111(3):280-288.

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Manara MC, Terracciano M, Mancarella C, Sciandra M, Guerzoni C, Pasello M, Grilli A, Zini N, Picci P, Colombo MP, Morrione A, Scotlandi K. CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget. 2016 Nov 29; 7(48):79925-79942.

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Vu HL, Rosenbaum S, Purwin TJ, Davies MA, Aplin AE. RAC1 P29S regulates PD-L1 expression in melanoma. Pigment Cell Melanoma Res. 2015 Sep; 28(5):590-8.

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Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK. CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015 Mar 02; 125(3):1019-32.

View in: PubMed

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