"Hemidesmosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.
| Descriptor ID |
D022002
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| MeSH Number(s) |
A11.284.149.165.165.360
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemidesmosomes".
Below are MeSH descriptors whose meaning is more specific than "Hemidesmosomes".
This graph shows the total number of publications written about "Hemidesmosomes" by people in this website by year, and whether "Hemidesmosomes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
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Below are the most recent publications written about "Hemidesmosomes" by people in Profiles.
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Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM. Keratinocyte-targeted expression of human laminin ?2 rescues skin blistering and early lethality of laminin ?2 deficient mice. PLoS One. 2012; 7(9):e45546.
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Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, Ghafoor S, Young NJ, Okamatsu Y, McGrath J, Koopman P, Sharpe PT, Ohazama A. Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS One. 2012; 7(9):e43857.
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Groves RW, Liu L, Dopping-Hepenstal PJ, Markus HS, Lovell PA, Ozoemena L, Lai-Cheong JE, Gawler J, Owaribe K, Hashimoto T, Mellerio JE, Mee JB, McGrath JA. A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex. J Invest Dermatol. 2010 Jun; 130(6):1551-7.
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Fassihi H, Wong T, Wessagowit V, McGrath JA, Mellerio JE. Target proteins in inherited and acquired blistering skin disorders. Clin Exp Dermatol. 2006 Mar; 31(2):252-9.
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Nguyen NM, Pulkkinen L, Schlueter JA, Meneguzzi G, Uitto J, Senior RM. Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation. Respir Res. 2006 Feb 16; 7:28.
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Varki R, Sadowski S, Pfendner E, Uitto J. Epidermolysis bullosa. I. Molecular genetics of the junctional and hemidesmosomal variants. J Med Genet. 2006 Aug; 43(8):641-52.
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McGrath JA. Keratinocyte adhesion and the missing link: from Dowling-Meara to Hay-Wells. St John's Hospital Dermatological Society Annual Oration 2000. Clin Exp Dermatol. 2001 May; 26(3):296-304.