"HMGA1a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.
| Descriptor ID |
D025741
|
| MeSH Number(s) |
D12.776.260.312.500 D12.776.660.235.400.500.100 D12.776.664.235.400.500.100
|
| Concept/Terms |
HMGA1a Protein- HMGA1a Protein
- High Mobility Group I(Y) Protein
- HMGI(Y) Gene Product
- HMG I-Y Phosphoprotein
- HMG I Y Phosphoprotein
- Phosphoprotein, HMG I-Y
- HMG-I(Y) Protein
- HMGI Protein
- AT-Hook 1a Protein, High Mobility Group
- AT Hook 1a Protein, High Mobility Group
- HMG I-Type Protein
- HMG I Type Protein
|
Below are MeSH descriptors whose meaning is more general than "HMGA1a Protein".
Below are MeSH descriptors whose meaning is more specific than "HMGA1a Protein".
This graph shows the total number of publications written about "HMGA1a Protein" by people in this website by year, and whether "HMGA1a Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "HMGA1a Protein" by people in Profiles.
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Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A. Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006 Mar 01; 66(5):2536-43.
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Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C, Viglietto G, Croce CM, Fusco A. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene. 2005 May 12; 24(21):3427-35.