RNA, Small Interfering

"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Descriptor ID	D034741
MeSH Number(s)	D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
Concept/Terms	RNA, Small Interfering RNA, Small Interfering Interfering RNA, Small Short Interfering RNA Interfering RNA, Short RNA, Short Interfering Small Interfering RNA siRNA Piwi-Interacting RNA Piwi-Interacting RNA Piwi Interacting RNA RNA, Piwi-Interacting RNA, Piwi Interacting piRNA Short Hairpin RNA Short Hairpin RNA Hairpin RNA, Short RNA, Short Hairpin Small Hairpin RNA Hairpin RNA, Small RNA, Small Hairpin shRNA Repeat-Associated siRNA Repeat-Associated siRNA Repeat Associated siRNA siRNA, Repeat-Associated siRNA, Repeat Associated Scan RNA Scan RNA scnRNA Small Scan RNA RNA, Small Scan Scan RNA, Small RNA, Scan Trans-Acting siRNA Trans-Acting siRNA Trans Acting siRNA tasiRNA siRNA, Trans-Acting siRNA, Trans Acting

Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
RNA, Antisense [D13.150.650]
RNA, Small Interfering [D13.150.650.700]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Antisense [D13.444.735.150]
RNA, Small Interfering [D13.444.735.150.700]
RNA, Untranslated [D13.444.735.790]
RNA, Small Untranslated [D13.444.735.790.552]
RNA, Small Interfering [D13.444.735.790.552.875]

Below are MeSH descriptors whose meaning is related to "RNA, Small Interfering".

Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.

Bar chart showing 205 publications over 23 distinct years, with a maximum of 25 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	1	1	2
2004	2	3	5
2005	0	6	6
2006	2	7	9
2007	2	12	14
2008	1	7	8
2009	3	17	20
2010	1	16	17
2011	3	22	25
2012	3	9	12
2013	1	22	23
2014	5	8	13
2015	1	8	9
2016	1	6	7
2017	1	7	8
2018	0	5	5
2019	0	5	5
2020	0	3	3
2021	1	2	3
2022	0	5	5
2023	0	1	1
2024	1	3	4

Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.

Porat-Dahlerbruch G, Sergeyev IV, Quinn CM, Struppe J, Banks D, Dahlheim C, Johnson D, Murphy D, Ilott A, Abraham A, Polenova T. Spatial Organization of Lipid Nanoparticle siRNA Delivery Systems Revealed by an Integrated Magnetic Resonance Approach. Small Methods. 2025 01; 9(1):e2400622.

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Ghosh S, Jana R, Jana S, Basu R, Chatterjee M, Ranawat N, Das Sarma J. Differential expression of cellular prion protein (PrPC) in mouse hepatitis virus induced neuroinflammation. J Neurovirol. 2024 06; 30(3):215-228.

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Brenneman DE, Kinney WA, McDonnell ME, Ippolito MJ, Ward SJ. Knockdown siRNA Targeting GPR55 Reveals Significant Differences Between the Anti-inflammatory Actions of KLS-13019 and Cannabidiol. J Mol Neurosci. 2024 Apr 11; 74(2):41.

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Zhao L, Wang Y, Sun X, Zhang X, Simone N, He J. ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer. Int J Mol Sci. 2024 Feb 17; 25(4).

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Miley DR, Andrews-Pfannkoch CM, Pulido JS, Erickson SA, Vile RG, Fautsch MP, Marmorstein AD, Dalvin LA. Direct early growth response-1 knockdown decreases melanoma viability independent of mitogen-activated extracellular signal-related kinase inhibition. Melanoma Res. 2023 12 01; 33(6):482-491.

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Krishn SR, Garcia V, Naranjo NM, Quaglia F, Shields CD, Harris MA, Kossenkov AV, Liu Q, Corey E, Altieri DC, Languino LR. Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the aV?6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer Biol Ther. 2022 12 31; 23(1):173-185.

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Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo RV, Giordano A, Morrione A. Complexity of progranulin mechanisms of action in mesothelioma. J Exp Clin Cancer Res. 2022 Dec 05; 41(1):333.

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Celik B, Cicek K, Leal AF, Tomatsu S. Regulation of Molecular Targets in Osteosarcoma Treatment. Int J Mol Sci. 2022 Oct 20; 23(20).

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Brown SZ, McCarthy GA, Carroll JR, Di Niro R, Pelz C, Jain A, Sutton TL, Holly HD, Nevler A, Schultz CW, McCoy MD, Cozzitorto JA, Jiang W, Yeo CJ, Dixon DA, Sears RC, Brody JR. The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. Mol Cell Biol. 2022 07 21; 42(7):e0001822.

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Xue L, Gong N, Shepherd SJ, Xiong X, Liao X, Han X, Zhao G, Song C, Huang X, Zhang H, Padilla MS, Qin J, Shi Y, Alameh MG, Pochan DJ, Wang K, Long F, Weissman D, Mitchell MJ. Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J Am Chem Soc. 2022 06 08; 144(22):9926-9937.

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