"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
| Descriptor ID |
D034741
|
| MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
|
| Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
|
Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 4 | 5 |
| 2004 | 3 | 6 | 9 |
| 2005 | 0 | 12 | 12 |
| 2006 | 5 | 13 | 18 |
| 2007 | 5 | 26 | 31 |
| 2008 | 2 | 24 | 26 |
| 2009 | 7 | 26 | 33 |
| 2010 | 3 | 25 | 28 |
| 2011 | 7 | 32 | 39 |
| 2012 | 5 | 19 | 24 |
| 2013 | 6 | 37 | 43 |
| 2014 | 6 | 23 | 29 |
| 2015 | 3 | 13 | 16 |
| 2016 | 4 | 13 | 17 |
| 2017 | 6 | 11 | 17 |
| 2018 | 2 | 9 | 11 |
| 2019 | 1 | 8 | 9 |
| 2020 | 1 | 8 | 9 |
| 2021 | 2 | 7 | 9 |
| 2022 | 0 | 6 | 6 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 4 | 5 |
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Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Porat-Dahlerbruch G, Sergeyev IV, Quinn CM, Struppe J, Banks D, Dahlheim C, Johnson D, Murphy D, Ilott A, Abraham A, Polenova T. Spatial Organization of Lipid Nanoparticle siRNA Delivery Systems Revealed by an Integrated Magnetic Resonance Approach. Small Methods. 2025 01; 9(1):e2400622.
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Ghosh S, Jana R, Jana S, Basu R, Chatterjee M, Ranawat N, Das Sarma J. Differential expression of cellular prion protein (PrPC) in mouse hepatitis virus induced neuroinflammation. J Neurovirol. 2024 06; 30(3):215-228.
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Brenneman DE, Kinney WA, McDonnell ME, Ippolito MJ, Ward SJ. Knockdown siRNA Targeting GPR55 Reveals Significant Differences Between the Anti-inflammatory Actions of KLS-13019 and Cannabidiol. J Mol Neurosci. 2024 Apr 11; 74(2):41.
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Roh EH, Sullivan MO, Epps TH. Which Lipid Nanoparticle (LNP) Designs Work? A Simple Kinetic Model Linking LNP Chemical Structure to In Vivo Delivery Performance. ACS Appl Mater Interfaces. 2024 Mar 20; 16(11):13399-13410.
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Zhao L, Wang Y, Sun X, Zhang X, Simone N, He J. ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer. Int J Mol Sci. 2024 Feb 17; 25(4).
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Miley DR, Andrews-Pfannkoch CM, Pulido JS, Erickson SA, Vile RG, Fautsch MP, Marmorstein AD, Dalvin LA. Direct early growth response-1 knockdown decreases melanoma viability independent of mitogen-activated extracellular signal-related kinase inhibition. Melanoma Res. 2023 12 01; 33(6):482-491.
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Krishn SR, Garcia V, Naranjo NM, Quaglia F, Shields CD, Harris MA, Kossenkov AV, Liu Q, Corey E, Altieri DC, Languino LR. Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the aV?6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer Biol Ther. 2022 12 31; 23(1):173-185.
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Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo RV, Giordano A, Morrione A. Complexity of progranulin mechanisms of action in mesothelioma. J Exp Clin Cancer Res. 2022 Dec 05; 41(1):333.
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Roh EH, Sullivan MO, Epps TH. A kinetic modeling platform for predicting the efficacy of siRNA formulations in?vitro and in?vivo. STAR Protoc. 2022 12 16; 3(4):101723.
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Celik B, Cicek K, Leal AF, Tomatsu S. Regulation of Molecular Targets in Osteosarcoma Treatment. Int J Mol Sci. 2022 Oct 20; 23(20).