Pulmonary Surfactant-Associated Protein A
"Pulmonary Surfactant-Associated Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
| Descriptor ID |
D037662
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| MeSH Number(s) |
D12.776.503.280.249.600 D12.776.823.100
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pulmonary Surfactant-Associated Protein A".
Below are MeSH descriptors whose meaning is more specific than "Pulmonary Surfactant-Associated Protein A".
This graph shows the total number of publications written about "Pulmonary Surfactant-Associated Protein A" by people in this website by year, and whether "Pulmonary Surfactant-Associated Protein A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pulmonary Surfactant-Associated Protein A" by people in Profiles.
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Gad A, Callender DL, Killeen E, Hudak J, Dlugosz MA, Larson JE, Cohen JC, Chander A. Transient in utero disruption of cystic fibrosis transmembrane conductance regulator causes phenotypic changes in alveolar type II cells in adult rats. BMC Cell Biol. 2009 Mar 31; 10:24.
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Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1052-63.
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Inselman LS, Chander A, Spitzer AR. Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats. Lung. 2004; 182(2):101-17.
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White MK, Strayer DS. Survival signaling in type II pneumocytes activated by surfactant protein-A. Exp Cell Res. 2002 Nov 01; 280(2):270-9.
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White MK, Baireddy V, Strayer DS. Natural protection from apoptosis by surfactant protein A in type II pneumocytes. Exp Cell Res. 2001 Feb 15; 263(2):183-92.
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Strayer DS, Korutla L. Activation of surfactant protein-B transcription: signaling through the SP-A receptor utilizing the PI3 kinase pathway. J Cell Physiol. 2000 Aug; 184(2):229-38.
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White MK, Strayer DS. Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells. Exp Cell Res. 2000 Feb 25; 255(1):67-76.
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Strayer DS, Hoek JB, Thomas AP, White MK. Cellular activation by Ca2+ release from stores in the endoplasmic reticulum but not by increased free Ca2+ in the cytosol. Biochem J. 1999 Nov 15; 344 Pt 1:39-46.
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Korutla L, Strayer DS. SP-A as a cytokine: surfactant protein-A-regulated transcription of surfactant proteins and other genes. J Cell Physiol. 1999 Mar; 178(3):379-86.
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Chen Q, Fisher AB, Strayer DS, Bates SR. Mechanism for secretagogue-induced surfactant protein A binding to lung epithelial cells. Am J Physiol. 1998 07; 275(1):L38-46.