Prokaryotic Initiation Factor-3
"Prokaryotic Initiation Factor-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.
| Descriptor ID |
D039665
|
| MeSH Number(s) |
D12.776.835.725.934.750
|
| Concept/Terms |
Prokaryotic Initiation Factor-3- Prokaryotic Initiation Factor-3
- Initiation Factor-3, Prokaryotic
- Prokaryotic Initiation Factor 3
- Peptide Initiation Factor 3
- Translation Initiation Factor 3
- Prokaryotic Peptide Initiation Factor-3
- Prokaryotic Peptide Initiation Factor 3
- TIF IF3
- Initiation Factor IF-3
- IF-3, Initiation Factor
- Initiation Factor IF 3
- Peptide Initiation Factor IF-3
- Peptide Initiation Factor IF 3
|
Below are MeSH descriptors whose meaning is more general than "Prokaryotic Initiation Factor-3".
Below are MeSH descriptors whose meaning is more specific than "Prokaryotic Initiation Factor-3".
This graph shows the total number of publications written about "Prokaryotic Initiation Factor-3" by people in this website by year, and whether "Prokaryotic Initiation Factor-3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
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Below are the most recent publications written about "Prokaryotic Initiation Factor-3" by people in Profiles.
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Chen Y, Kaji A, Kaji H, Cooperman BS. The kinetic mechanism of bacterial ribosome recycling. Nucleic Acids Res. 2017 Sep 29; 45(17):10168-10177.
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Iwakura N, Yokoyama T, Quaglia F, Mitsuoka K, Mio K, Shigematsu H, Shirouzu M, Kaji A, Kaji H. Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G. PLoS One. 2017; 12(5):e0177972.
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Hirokawa G, Iwakura N, Kaji A, Kaji H. The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G). Nucleic Acids Res. 2008 Dec; 36(21):6676-87.
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Hirokawa G, Kaji H, Kaji A. Inhibition of antiassociation activity of translation initiation factor 3 by paromomycin. Antimicrob Agents Chemother. 2007 Jan; 51(1):175-80.
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Hirokawa G, Nijman RM, Raj VS, Kaji H, Igarashi K, Kaji A. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA. 2005 Aug; 11(8):1317-28.