"Receptor, Adenosine A2A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.
| Descriptor ID |
D043705
|
| MeSH Number(s) |
D12.776.543.750.695.700.700.200.100 D12.776.543.750.720.700.700.200.100
|
| Concept/Terms |
Receptor, Adenosine A2A- Receptor, Adenosine A2A
- A2A Receptor, Adenosine
- Adenosine A(2A) Receptor
- Adenosine A2A Receptor
- Adenosine A2A Receptors
- A2A Receptors, Adenosine
- Receptors, Adenosine A2A
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Adenosine A2A".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Purinergic [D12.776.543.750.695.700]
- Receptors, Purinergic P1 [D12.776.543.750.695.700.700]
- Receptors, Adenosine A2 [D12.776.543.750.695.700.700.200]
- Receptor, Adenosine A2A [D12.776.543.750.695.700.700.200.100]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Purinergic [D12.776.543.750.720.700]
- Receptors, Purinergic P1 [D12.776.543.750.720.700.700]
- Receptors, Adenosine A2 [D12.776.543.750.720.700.700.200]
- Receptor, Adenosine A2A [D12.776.543.750.720.700.700.200.100]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Adenosine A2A".
This graph shows the total number of publications written about "Receptor, Adenosine A2A" by people in this website by year, and whether "Receptor, Adenosine A2A" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptor, Adenosine A2A" by people in Profiles.
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Naik SD, Kim M, Choi J, Kim G, Woo Kim S, Aswar VR, Tripathi SK, Gaikwad V, Yu J, Shin Jeong L. Exploring C2 and N6 Substituent Effects on Truncated 4'-Thioadenosine Derivatives as Dual A2A and A3 Adenosine Receptor Ligands. ChemMedChem. 2025 Feb 16; 20(4):e202400575.
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Pak ES, Jeong LS, Hou X, Tripathi SK, Lee J, Ha H. Dual Actions of A2A and A3 Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice. Int J Mol Sci. 2021 May 26; 22(11).
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McNeely PM, Naranjo AN, Forsten-Williams K, Robinson AS. A2AR Binding Kinetics in the Ligand Depletion Regime. SLAS Discov. 2017 02; 22(2):166-175.
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Dahan R, Ravetch JV. Co-targeting of Adenosine Signaling Pathways for Immunotherapy: Potentiation by Fc Receptor Engagement. Cancer Cell. 2016 09 12; 30(3):369-371.
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Naranjo AN, McNeely PM, Katsaras J, Robinson AS. Impact of purification conditions and history on A2A adenosine receptor activity: The role of CHAPS and lipids. Protein Expr Purif. 2016 08; 124:62-7.
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Naranjo AN, Chevalier A, Cousins GD, Ayettey E, McCusker EC, Wenk C, Robinson AS. Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition. Biochim Biophys Acta. 2015 Feb; 1848(2):603-14.
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Collins LE, Sager TN, Sams AG, Pennarola A, Port RG, Shahriari M, Salamone JD. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan; 100(3):498-505.
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O'Malley MA, Helgeson ME, Wagner NJ, Robinson AS. Toward rational design of protein detergent complexes: determinants of mixed micelles that are critical for the in vitro stabilization of a G-protein coupled receptor. Biophys J. 2011 Oct 19; 101(8):1938-48.
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Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM. Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1738-47.
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O'Malley MA, Mancini JD, Young CL, McCusker EC, Raden D, Robinson AS. Progress toward heterologous expression of active G-protein-coupled receptors in Saccharomyces cerevisiae: Linking cellular stress response with translocation and trafficking. Protein Sci. 2009 Nov; 18(11):2356-70.