"Thymine DNA Glycosylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.
| Descriptor ID |
D044502
|
| MeSH Number(s) |
D08.811.074.249.750 D08.811.277.450.430.099.750
|
| Concept/Terms |
Thymine DNA Glycosylase- Thymine DNA Glycosylase
- DNA Glycosylase, Thymine
- Glycosylase, Thymine DNA
- Thymine Glycol Glycosylase
- Glycol Glycosylase, Thymine
- Glycosylase, Thymine Glycol
- G-T Mismatch-Specific Thymine DNA Glycosylase
- G T Mismatch Specific Thymine DNA Glycosylase
- Thymine Glycol DNA Glycosylase
|
Below are MeSH descriptors whose meaning is more general than "Thymine DNA Glycosylase".
Below are MeSH descriptors whose meaning is more specific than "Thymine DNA Glycosylase".
This graph shows the total number of publications written about "Thymine DNA Glycosylase" by people in this website by year, and whether "Thymine DNA Glycosylase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Thymine DNA Glycosylase" by people in Profiles.
-
Hashimoto H, Zhang X, Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst). 2013 Jul; 12(7):535-40.
-
Hashimoto H, Zhang X, Cheng X. Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol. 2013 Mar 25; 425(6):971-6.
-
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 08; 146(1):67-79.
-
Cortellino S, Turner D, Masciullo V, Schepis F, Albino D, Daniel R, Skalka AM, Meropol NJ, Alberti C, Larue L, Bellacosa A. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):15071-6.