Esophageal Sphincter, Lower

"Esophageal Sphincter, Lower" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)

Descriptor ID	D049630
MeSH Number(s)	A02.633.570.210 A03.556.875.500.414.350 A03.556.875.875.330.350
Concept/Terms	Esophageal Sphincter, Lower Esophageal Sphincter, Lower Sphincter, Lower Esophageal Lower Esophageal Sphincter

Below are MeSH descriptors whose meaning is more general than "Esophageal Sphincter, Lower".

Anatomy [A]
Musculoskeletal System [A02]
Muscles [A02.633]
Muscle, Smooth [A02.633.570]
Esophageal Sphincter, Lower [A02.633.570.210]
Digestive System [A03]
Gastrointestinal Tract [A03.556]
Upper Gastrointestinal Tract [A03.556.875]
Esophagus [A03.556.875.500]
Esophagogastric Junction [A03.556.875.500.414]
Esophageal Sphincter, Lower [A03.556.875.500.414.350]
Stomach [A03.556.875.875]
Esophagogastric Junction [A03.556.875.875.330]
Esophageal Sphincter, Lower [A03.556.875.875.330.350]

Below are MeSH descriptors whose meaning is related to "Esophageal Sphincter, Lower".

Below are MeSH descriptors whose meaning is more specific than "Esophageal Sphincter, Lower".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Esophageal Sphincter, Lower" by people in this website by year, and whether "Esophageal Sphincter, Lower" was a major or minor topic of these publications.

Bar chart showing 10 publications over 6 distinct years, with a maximum of 3 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2020	0	1	1
2021	0	1	1
2022	1	1	2
2023	0	2	2
2024	1	2	3

Below are the most recent publications written about "Esophageal Sphincter, Lower" by people in Profiles.

Hayat U, Kamal F, Rana UI, Iqbal A, Gangwani MK, Ali H, Gopalakrishnan K, Farooq U, Khan HMA, Kumar K, Adler DG. Efficacy and Safety of Repeat Per-oral Endoscopic Myotomy After Failed POEM for Achalasia: A Systematic Review and meta-analysis. J Clin Gastroenterol. 2025 Nov-Dec 01; 59(10):1000-1007.

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Swei E, Kassir Z, Shrigiriwar AP, Schlacterman A, Chung CS, Mandarino FV, Kedia P, Messman H, Pawa R, Desai P, Saxena P, Assefa R, Arevalo-Mora M, Azzolini F, Arcidiacono PG, Nagl S, Abu-Hammour MN, Puga-Tejada M, Baquerizo-Burgos J, Egas-Izquierdo M, Cunto D, Alcivar-Vasquez J, Del Valle R, Sharaiha RZ, Irani S, Medranda CR, Khashab M. Short esophageal myotomy versus standard myotomy for treatment of sigmoid-type achalasia: results of an international multicenter study. Gastrointest Endosc. 2025 02; 101(2):377-384.e2.

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Ikeda H, Ihara E, Takeya K, Mukai K, Onimaru M, Ouchida K, Hata Y, Bai X, Tanaka Y, Sasaki T, Saito F, Eto M, Nakayama J, Oda Y, Nakamura M, Inoue H, Ogawa Y. The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia. J Gastroenterol. 2024 05; 59(5):361-375.

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Gomez J, Felder L, Chalikonda D, Schlachterman A, Berghella V. Per Oral Endoscopic Myotomy in pregnancy. J Matern Fetal Neonatal Med. 2023 Dec; 36(2):2229474.

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Ichkhanian Y, Al-Haddad MA, Jacobs CC, Schlachterman A, Yang J, Canakis A, Kim R, Guerson-Gil A, D'Souza LS, Alsheik E, Ginnebaugh BD, Khashab MA, Zuchelli T, McFarlin K, Piraka C. Gastric peroral endoscopic myotomy for management of refractory gastroparesis in patients with gastric neurostimulator devices: a multicenter retrospective case control study. Gastrointest Endosc. 2023 10; 98(4):559-566.e1.

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Ichkhanian Y, Brewer Gutierrez O, Roman S, Yoo IK, Canakis A, Pawa R, Koch K, Su B, Ujiki M, Alsheik E, Zuchelli T, Piraka C, Ghandour B, Zhang L, Sloan JA, Khashab MA. Role of functional luminal imaging probe in the management of postmyotomy clinical failure. Gastrointest Endosc. 2022 07; 96(1):9-17.e3.

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Balouch B, Vaid A, Vontela S, Alnouri G, Sataloff RT. Anatomic and Manometric Abnormalities of the Upper and Lower Esophageal Sphincters in Patients With Reflux Disease. J Voice. 2024 May; 38(3):746-753.

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Kamal F, Khan MA, Lee-Smith W, Sharma S, Acharya A, Jowhar D, Farooq U, Aziz M, Kouanda A, Dai SC, Howden CW, Munroe CA. Systematic review with meta-analysis: one-year outcomes of gastric peroral endoscopic myotomy for refractory gastroparesis. Aliment Pharmacol Ther. 2022 01; 55(2):168-177.

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Ranjbar PA, Alnouri G, Vance D, Park J, Suresh A, Acharya P, Sataloff RT. The Prevalence of Esophageal Disorders Among Voice Patients With Laryngopharyngeal Reflux-A Retrospective Study. J Voice. 2022 May; 36(3):410-412.

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Fisichella PM, Raz D, Palazzo F, Niponmick I, Patti MG. Clinical, radiological, and manometric profile in 145 patients with untreated achalasia. World J Surg. 2008 Sep; 32(9):1974-9.

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