"Synaptotagmin I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.
| Descriptor ID |
D050863
|
| MeSH Number(s) |
D12.776.157.125.825.249 D12.776.543.990.850.249
|
| Concept/Terms |
Synaptotagmin I- Synaptotagmin I
- p65 Protein (Synaptotagmin I)
- Synaptic Vesicle Protein p65
- Synaptotagmin 1
|
Below are MeSH descriptors whose meaning is more general than "Synaptotagmin I".
Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin I".
This graph shows the total number of publications written about "Synaptotagmin I" by people in this website by year, and whether "Synaptotagmin I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synaptotagmin I" by people in Profiles.
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Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Laulund LW, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian MA, Scott DJ, Ziarek JJ, Gordon SL, Baker K. Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder. Genet Med. 2022 04; 24(4):880-893.
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Giraudo CG, Garcia-Diaz A, Eng WS, Yamamoto A, Melia TJ, Rothman JE. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem. 2008 Jul 25; 283(30):21211-9.
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Giraudo CG, Eng WS, Melia TJ, Rothman JE. A clamping mechanism involved in SNARE-dependent exocytosis. Science. 2006 Aug 04; 313(5787):676-80.