"Farnesyltranstransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.
| Descriptor ID |
D051231
|
| MeSH Number(s) |
D08.811.913.225.437
|
| Concept/Terms |
Farnesyltranstransferase- Farnesyltranstransferase
- Farnesyltransferase
- Geranylgeranyl Pyrophosphatase
- Pyrophosphatase, Geranylgeranyl
- GGDP Synthase
- Synthase, GGDP
- GGPP Synthase
- Synthase, GGPP
- Farnesyl Diphosphate-Geranylgeranyl Diphosphate Synthase
- Farnesyl Diphosphate Geranylgeranyl Diphosphate Synthase
- Geranylgeranyl-Diphosphate Synthase
- Geranylgeranyl Diphosphate Synthase
- Synthase, Geranylgeranyl-Diphosphate
|
Below are MeSH descriptors whose meaning is more general than "Farnesyltranstransferase".
Below are MeSH descriptors whose meaning is more specific than "Farnesyltranstransferase".
This graph shows the total number of publications written about "Farnesyltranstransferase" by people in this website by year, and whether "Farnesyltranstransferase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Farnesyltranstransferase" by people in Profiles.
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Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Harrington LS, Louise H, Prendergast GC, Wilkins MR. Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia. Circ Res. 2012 May 25; 110(11):1423-34.
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Bendell J, Goldberg RM. Targeted agents in the treatment of pancreatic cancer: history and lessons learned. Curr Opin Oncol. 2007 Jul; 19(4):390-5.
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Kamasani U, Duhadaway JB, Alberts AS, Prendergast GC. mDia function is critical for the cell suicide program triggered by farnesyl transferase inhibition. Cancer Biol Ther. 2007 Sep; 6(9):1422-7.
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Huang M, Prendergast GC. RhoB in cancer suppression. Histol Histopathol. 2006 02; 21(2):213-8.
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Kamasani U, Huang M, Duhadaway JB, Prochownik EV, Donover PS, Prendergast GC. Cyclin B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition. Cancer Res. 2004 Nov 15; 64(22):8389-96.
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Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE. RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 2003 Nov 01; 17(21):2721-32.
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Adjei AA, Croghan GA, Erlichman C, Marks RS, Reid JM, Sloan JA, Pitot HC, Alberts SR, Goldberg RM, Hanson LJ, Bruzek LM, Atherton P, Thibault A, Palmer PA, Kaufmann SH. A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res. 2003 Jul; 9(7):2520-6.
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DuHadaway JB, Du W, Donover S, Baker J, Liu AX, Sharp DM, Muller AJ, Prendergast GC. Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1. Oncogene. 2003 Jun 05; 22(23):3578-88.
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Kamasani U, Liu AX, Prendergast GC. Genetic response to farnesyltransferase inhibitors: proapoptotic targets of RhoB. Cancer Biol Ther. 2003 May-Jun; 2(3):273-80.
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Zeng PY, Rane N, Du W, Chintapalli J, Prendergast GC. Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors. Oncogene. 2003 Feb 27; 22(8):1124-34.