Desmoglein 2

"Desmoglein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CALCIUM-dependent adhesion molecule of DESMOSOMES that also plays a role in embryonic STEM CELL proliferation.

Descriptor ID	D051301
MeSH Number(s)	D12.776.395.550.200.200.500.500.625 D12.776.543.550.200.200.500.500.625 D23.050.301.350.200.500.500.625
Concept/Terms	Desmoglein 2 Desmoglein 2 Desmoglein II Desmosomal Glycoprotein 2

Below are MeSH descriptors whose meaning is more general than "Desmoglein 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Cell Adhesion Molecules [D12.776.395.550.200]
Cadherins [D12.776.395.550.200.200]
Desmosomal Cadherins [D12.776.395.550.200.200.500]
Desmogleins [D12.776.395.550.200.200.500.500]
Desmoglein 2 [D12.776.395.550.200.200.500.500.625]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Cell Adhesion Molecules [D12.776.543.550.200]
Cadherins [D12.776.543.550.200.200]
Desmosomal Cadherins [D12.776.543.550.200.200.500]
Desmogleins [D12.776.543.550.200.200.500.500]
Desmoglein 2 [D12.776.543.550.200.200.500.500.625]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Cell Adhesion Molecules [D23.050.301.350]
Cadherins [D23.050.301.350.200]
Desmosomal Cadherins [D23.050.301.350.200.500]
Desmogleins [D23.050.301.350.200.500.500]
Desmoglein 2 [D23.050.301.350.200.500.500.625]

Below are MeSH descriptors whose meaning is related to "Desmoglein 2".

Below are MeSH descriptors whose meaning is more specific than "Desmoglein 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Desmoglein 2" by people in this website by year, and whether "Desmoglein 2" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2015 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2007	1	0	1
2011	1	0	1
2015	2	0	2
2016	1	0	1
2017	1	0	1
2018	2	0	2
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Desmoglein 2" by people in Profiles.

Xu T, Herkens L, Jia T, Klinkhammer BM, Kant S, Krusche CA, Buhl EM, Hayat S, Floege J, Strnad P, Kramann R, Djudjaj S, Boor P. The role of desmoglein-2 in kidney disease. Kidney Int. 2024 05; 105(5):1035-1048.

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Myo Min KK, Rojas-Canales D, Penko D, DeNichilo M, Cockshell MP, Ffrench CB, Thompson EJ, Asplund O, Drogemuller CJ, Prasad RB, Groop L, Grey ST, Thomas HE, Loudovaris T, Kay TW, Mahoney MG, Jessup CF, Coates PT, Bonder CS. Desmoglein-2 is important for islet function and ?-cell survival. Cell Death Dis. 2022 10 29; 13(10):911.

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Brennan-Crispi DM, Overmiller AM, Tamayo-Orrego L, Marous MR, Sahu J, McGuinn KP, Cooper F, Georgiou IC, Frankfurter M, Salas-Alanis JC, Charron F, Millar SE, Mahoney MG, Riobo-Del Galdo NA. Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression. J Invest Dermatol. 2019 02; 139(2):300-307.

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Cooper F, Overmiller AM, Loder A, Brennan-Crispi DM, McGuinn KP, Marous MR, Freeman TA, Riobo-Del Galdo NA, Siracusa LD, Wahl JK, Mahoney MG. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion. J Invest Dermatol. 2018 11; 138(11):2470-2479.

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Overmiller AM, Pierluissi JA, Wermuth PJ, Sauma S, Martinez-Outschoorn U, Tuluc M, Luginbuhl A, Curry J, Harshyne LA, Wahl JK, South AP, Mahoney MG. Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes. FASEB J. 2017 08; 31(8):3412-3424.

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Roberts BJ, Svoboda RA, Overmiller AM, Lewis JD, Kowalczyk AP, Mahoney MG, Johnson KR, Wahl JK. Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. J Biol Chem. 2016 Nov 25; 291(48):24857-24865.

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Brennan-Crispi DM, Hossain C, Sahu J, Brady M, Riobo NA, Mahoney MG. Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis. Oncotarget. 2015 Apr 20; 6(11):8593-605.

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Gupta A, Nitoiu D, Brennan-Crispi D, Addya S, Riobo NA, Kelsell DP, Mahoney MG. Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion. PLoS One. 2015; 10(3):e0120091.

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Brennan D, Peltonen S, Dowling A, Medhat W, Green KJ, Wahl JK, Del Galdo F, Mahoney MG. A role for caveolin-1 in desmoglein binding and desmosome dynamics. Oncogene. 2012 Mar 29; 31(13):1636-48.

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Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci. 2007 Mar 01; 120(Pt 5):758-71.

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