Nod2 Signaling Adaptor Protein
"Nod2 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
| Descriptor ID |
D053473
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| MeSH Number(s) |
D12.644.360.024.131.500 D12.644.360.024.313.500 D12.644.360.075.358.500 D12.644.360.539.500.500 D12.776.157.057.006.500 D12.776.157.057.078.500 D12.776.476.024.139.500 D12.776.476.024.391.500 D12.776.476.075.358.500
|
| Concept/Terms |
Nod2 Signaling Adaptor Protein- Nod2 Signaling Adaptor Protein
- CARD15 Protein
- Nucleotide Oligomerization Domain 2 Protein
- Caspase Recruitment Domain Protein 15
|
Below are MeSH descriptors whose meaning is more general than "Nod2 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod2 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod2 Signaling Adaptor Protein" by people in this website by year, and whether "Nod2 Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nod2 Signaling Adaptor Protein" by people in Profiles.
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Chen S, Putnik R, Li X, Diwaker A, Vasconcelos M, Liu S, Gondi S, Zhou J, Guo L, Xu L, Temme S, Bersch K, Hyland S, Yin J, Burstein E, Bahnson BJ, Gildersleeve JC, Grimes CL, Reinecker HC. PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal?mucosal protection. Nat Commun. 2025 Feb 21; 16(1):1864.
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Lauro ML, D'Ambrosio EA, Bahnson BJ, Grimes CL. Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infect Dis. 2017 04 14; 3(4):264-270.
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Amin SR, Pulido JS. Retinal vasculitis, aneurysms, and neovascularization in Blau syndrome. JAMA Ophthalmol. 2013 May; 131(5):677-80.
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Dickinson GS, Piccone H, Sun G, Lien E, Gatto L, Alugupalli KR. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun. 2010 Nov; 78(11):4579-88.