G-Quadruplexes

"G-Quadruplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

Descriptor ID	D054856
MeSH Number(s)	G02.111.570.820.486.550 G05.360.580.550
Concept/Terms	G-Quadruplexes G-Quadruplexes G Quadruplexes Guanine-Quadruplexes Guanine Quadruplexes Guanine-Tetrads Guanine-Tetrads Guanine Tetrads Guanine-Tetrad Guanine-Quartets Guanine Quartets Guanine-Quartet G-Quadruplexes, DNA G-Quadruplexes, DNA G Quadruplexes, DNA Tetraplex DNA DNA, Tetraplex DNA G-Quadruplexes DNA G Quadruplexes DNA, Quadruplex Quadruplex DNA G-Quadruplexes, RNA G-Quadruplexes, RNA G Quadruplexes, RNA RNA G-Quadruplexes RNA, G-Quadruplexes G-Quadruplexes RNA G-Quadruplexes RNAs RNA, G Quadruplexes RNAs, G-Quadruplexes

Below are MeSH descriptors whose meaning is more general than "G-Quadruplexes".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Nucleic Acid Conformation [G02.111.570.820.486]
G-Quadruplexes [G02.111.570.820.486.550]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Nucleic Acid Conformation [G05.360.580]
G-Quadruplexes [G05.360.580.550]

Below are MeSH descriptors whose meaning is related to "G-Quadruplexes".

Below are MeSH descriptors whose meaning is more specific than "G-Quadruplexes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "G-Quadruplexes" by people in this website by year, and whether "G-Quadruplexes" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2015 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2012	1	0	1
2014	0	1	1
2015	0	2	2
2016	0	2	2
2017	1	0	1
2018	1	0	1
2019	1	0	1
2020	1	0	1
2021	1	0	1

Below are the most recent publications written about "G-Quadruplexes" by people in Profiles.

Ozcan KA, Ghaffari LT, Haeusler AR. The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion. Sci Rep. 2021 12 01; 11(1):23213.

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Simko EAJ, Liu H, Zhang T, Velasquez A, Teli S, Haeusler AR, Wang J. G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA. Nucleic Acids Res. 2020 07 27; 48(13):7421-7438.

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Neckles C, Boer RE, Aboreden N, Cross AM, Walker RL, Kim BH, Kim S, Schneekloth JS, Caplen NJ. HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction. RNA. 2019 12; 25(12):1731-1750.

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Ibrahim F, Maragkakis M, Alexiou P, Mourelatos Z. Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis. Nat Struct Mol Biol. 2018 04; 25(4):302-310.

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Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D. Mechanism of Transcription Anti-termination in Human Mitochondria. Cell. 2017 Nov 16; 171(5):1082-1093.e13.

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Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL. Oxidative guanine base damage regulates human telomerase activity. Nat Struct Mol Biol. 2016 Dec; 23(12):1092-1100.

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Fouquerel E, Parikh D, Opresko P. DNA damage processing at telomeres: The ends justify the means. DNA Repair (Amst). 2016 08; 44:159-168.

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Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 2015 Sep 03; 525(7567):56-61.

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Agaronyan K, Morozov YI, Anikin M, Temiakov D. Mitochondrial biology. Replication-transcription switch in human mitochondria. Science. 2015 Jan 30; 347(6221):548-51.

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Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 2014 Mar 13; 507(7491):195-200.

View in: PubMed

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