"Click Chemistry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
| Descriptor ID |
D057930
|
| MeSH Number(s) |
E05.197.124 J01.897.836.249.124
|
| Concept/Terms |
Click Chemistry- Click Chemistry
- Chemistries, Click
- Chemistry, Click
- Click Chemistries
- Click Chemical Techniques
- Chemical Technique, Click
- Chemical Techniques, Click
- Click Chemical Technique
- Technique, Click Chemical
- Techniques, Click Chemical
Click Chemical Reactions- Click Chemical Reactions
- Chemical Reaction, Click
- Chemical Reactions, Click
- Click Chemical Reaction
- Reaction, Click Chemical
- Reactions, Click Chemical
|
Below are MeSH descriptors whose meaning is more general than "Click Chemistry".
Below are MeSH descriptors whose meaning is more specific than "Click Chemistry".
This graph shows the total number of publications written about "Click Chemistry" by people in this website by year, and whether "Click Chemistry" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
| 2023 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Click Chemistry" by people in Profiles.
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Yang DB, Zhang T, Blum JE, Kloxin CJ, Pochan DJ, Saven JG. Complementary Peptide Interactions Support the Ultra-Rigidity of Polymers of De Novo Designed Click-Functionalized Bundlemers. J Phys Chem B. 2025 02 06; 129(5):1462-1474.
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DiMartini ET, Kyker-Snowman K, Shreiber DI. A click chemistry-based, free radical-initiated delivery system for the capture and release of payloads. Drug Deliv. 2023 Dec; 30(1):2232952.
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Ou C, Li C, Zhang R, Yang Q, Zong G, Dai Y, Francis RL, Bournazos S, Ravetch JV, Wang LX. One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjug Chem. 2021 08 18; 32(8):1888-1897.
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Seliem IA, Panda SS, Girgis AS, Moatasim Y, Kandeil A, Mostafa A, Ali MA, Nossier ES, Rasslan F, Srour AM, Sakhuja R, Ibrahim TS, Abdel-Samii ZKM, Al-Mahmoudy AMM. New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2. Bioorg Chem. 2021 09; 114:105117.
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McGann CL, Dumm RE, Jurusik AK, Sidhu I, Kiick KL. Thiol-ene Photocrosslinking of Cytocompatible Resilin-Like Polypeptide-PEG Hydrogels. Macromol Biosci. 2016 Jan; 16(1):129-38.
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Lau HK, Kiick KL. Opportunities for multicomponent hybrid hydrogels in biomedical applications. Biomacromolecules. 2015 Jan 12; 16(1):28-42.
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Zhang S, Zou J, Zhang F, Elsabahy M, Felder SE, Zhu J, Pochan DJ, Wooley KL. Rapid and versatile construction of diverse and functional nanostructures derived from a polyphosphoester-based biomimetic block copolymer system. J Am Chem Soc. 2012 Nov 07; 134(44):18467-74.