"alpha 1-Antitrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
| Descriptor ID |
D000515
|
| MeSH Number(s) |
D12.644.861.035 D12.776.124.050.070 D12.776.124.790.106.085 D12.776.377.715.085.085 D12.776.395.068 D12.776.872.035
|
| Concept/Terms |
alpha 1-Antitrypsin- alpha 1-Antitrypsin
- alpha 1 Antitrypsin
- alpha 1 Antiprotease
- Antiprotease, alpha 1
- Serpin A1
- alpha 1-Protease Inhibitor
- Inhibitor, alpha 1-Protease
- alpha 1 Protease Inhibitor
- alpha 1-Proteinase Inhibitor
- Inhibitor, alpha 1-Proteinase
- alpha 1 Proteinase Inhibitor
- Trypsin Inhibitor, alpha 1-Antitrypsin
- Trypsin Inhibitor, alpha 1 Antitrypsin
- A1PI
- alpha 1-Antiproteinase
- 1-Antiproteinase, alpha
- alpha 1 Antiproteinase
|
Below are MeSH descriptors whose meaning is more general than "alpha 1-Antitrypsin".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antitrypsin".
This graph shows the total number of publications written about "alpha 1-Antitrypsin" by people in this website by year, and whether "alpha 1-Antitrypsin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "alpha 1-Antitrypsin" by people in Profiles.
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Mulkareddy V, Roman J. Pulmonary manifestations of alpha 1 antitrypsin deficiency. Am J Med Sci. 2024 07; 368(1):1-8.
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Languino LR, Hooper DC. Activated Extracellular Vesicles as New Therapeutic Targets? Trends Cell Biol. 2019 04; 29(4):276-278.
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Fink S, Schilsky ML. Inherited metabolic disease of the liver. Curr Opin Gastroenterol. 2007 May; 23(3):237-43.
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Cordelier P, Strayer DS. Using gene delivery to protect HIV-susceptible CNS cells: inhibiting HIV replication in microglia. Virus Res. 2006 Jun; 118(1-2):87-97.
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Duan YY, Wu J, Zhu JL, Liu SL, Ozaki I, Strayer DS, Zern MA. Gene therapy for human alpha1-antitrypsin deficiency in an animal model using SV40-derived vectors. Gastroenterology. 2004 Oct; 127(4):1222-32.
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Cordelier P, Strayer DS. Conditional expression of alpha1-antitrypsin delivered by recombinant SV40 vectors protects lymphocytes against HIV. Gene Ther. 2003 Dec; 10(26):2153-6.
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Cordelier P, Strayer DS. Mechanisms of alpha1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis. Biochim Biophys Acta. 2003 Jul 30; 1638(3):197-207.
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Cordelier P, Zern MA, Strayer DS. HIV-1 proprotein processing as a target for gene therapy. Gene Ther. 2003 Mar; 10(6):467-77.
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Mercapide J, Lopez De Cicco R, Bassi DE, Castresana JS, Thomas G, Klein-Szanto AJP. Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clin Cancer Res. 2002 06; 8(6):1740-6.
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Bassi DE, Lopez De Cicco R, Mahloogi H, Zucker S, Thomas G, Klein-Szanto AJ. Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10326-31.