"Amitriptyline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
| Descriptor ID |
D000639
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.100 D04.615.181.384.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amitriptyline".
Below are MeSH descriptors whose meaning is more specific than "Amitriptyline".
This graph shows the total number of publications written about "Amitriptyline" by people in this website by year, and whether "Amitriptyline" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
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Below are the most recent publications written about "Amitriptyline" by people in Profiles.
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Gon?alves AL, Martini Ferreira A, Ribeiro RT, Zukerman E, Cipolla-Neto J, Peres MF. Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. J Neurol Neurosurg Psychiatry. 2016 Oct; 87(10):1127-32.
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Rosen JM, Alioto A, Saps M. Advances in Pain-Predominant Functional Gastrointestinal Disorders in the Adolescent. Adolesc Med State Art Rev. 2016; 27(1):34-56.
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Scanlon KA, Stoppacher R, Blum LM, Starkey SJ. Comprehensive Duloxetine Analysis in a Fatal Overdose. J Anal Toxicol. 2016 Mar; 40(2):167-70.
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Minoura Y, Di Diego JM, Barajas-Mart?nez H, Zygmunt AC, Hu D, Sicouri S, Antzelevitch C. Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. J Cardiovasc Electrophysiol. 2012 Apr; 23(4):423-32.
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Couch JR. Amitriptyline in the prophylactic treatment of migraine and chronic daily headache. Headache. 2011 Jan; 51(1):33-51.
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Tepper SJ. The role of prevention. Handb Clin Neurol. 2010; 97:195-205.
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Dodick DW, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg SJ, Hulihan J. Topiramate versus amitriptyline in migraine prevention: a 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. Clin Ther. 2009 Mar; 31(3):542-59.
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Silberstein SD, Winner PK, Chmiel JJ. Migraine preventive medication reduces resource utilization. Headache. 2003 Mar; 43(3):171-8.
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Way BA, Stickle D, Mitchell ME, Koenig JW, Turk J. Isotope dilution gas chromatographic-mass spectrometric measurement of tricyclic antidepressant drugs. Utility of the 4-carbethoxyhexafluorobutyryl derivatives of secondary amines. J Anal Toxicol. 1998 Sep; 22(5):374-82.
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Schulz P, Walser A, Meyer JJ, Kubli A, Garrone G. [French translation of the Stanford Sleepiness Scale and use of this scale of sedation following a single dose of midazolam or amitriptyline]. Agressologie. 1983 Sep; 24(8):357-9.