Arachidonate 15-Lipoxygenase

"Arachidonate 15-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.

Descriptor ID	D001093
MeSH Number(s)	D08.811.682.690.416.583.500.065 D12.776.556.579.374.568.500.030
Concept/Terms	Arachidonate 15-Lipoxygenase Arachidonate 15-Lipoxygenase 15-Lipoxygenase, Arachidonate Arachidonate 15 Lipoxygenase Arachidonic Acid 15-Lipoxygenase 15-Lipoxygenase, Arachidonic Acid Arachidonic Acid 15 Lipoxygenase 15-Lipoxygenase 15 Lipoxygenase

Below are MeSH descriptors whose meaning is more general than "Arachidonate 15-Lipoxygenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Dioxygenases [D08.811.682.690.416]
Lipoxygenases [D08.811.682.690.416.583]
Arachidonate Lipoxygenases [D08.811.682.690.416.583.500]
Arachidonate 15-Lipoxygenase [D08.811.682.690.416.583.500.065]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Metalloproteins [D12.776.556]
Iron-Binding Proteins [D12.776.556.579]
Nonheme Iron Proteins [D12.776.556.579.374]
Lipoxygenases [D12.776.556.579.374.568]
Arachidonate Lipoxygenases [D12.776.556.579.374.568.500]
Arachidonate 15-Lipoxygenase [D12.776.556.579.374.568.500.030]

Below are MeSH descriptors whose meaning is related to "Arachidonate 15-Lipoxygenase".

Below are MeSH descriptors whose meaning is more specific than "Arachidonate 15-Lipoxygenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Arachidonate 15-Lipoxygenase" by people in this website by year, and whether "Arachidonate 15-Lipoxygenase" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 3 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2014	1	0	1
2018	1	0	1
2020	3	0	3
2021	0	1	1
2023	0	2	2

Below are the most recent publications written about "Arachidonate 15-Lipoxygenase" by people in Profiles.

Tran M, Stanger L, Narendra S, Holinstat M, Holman TR. Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products. Arch Biochem Biophys. 2023 10 01; 747:109742.

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Yamaguchi A, van Hoorebeke C, Tourdot BE, Perry SC, Lee G, Rhoads N, Rickenberg A, Green AR, Sorrentino J, Yeung J, Freedman JC, Holman TR, Holinstat M. Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. Pharmacol Res Perspect. 2023 02; 11(1):e01056.

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Tsai WC, Kalyanaraman C, Yamaguchi A, Holinstat M, Jacobson MP, Holman TR. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 06 08; 60(22):1741-1754.

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Perry SC, Horn T, Tourdot BE, Yamaguchi A, Kalyanaraman C, Conrad WS, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. 2020 10 27; 59(42):4118-4130.

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Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR. 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. J Lipid Res. 2020 07; 61(7):1087-1103.

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Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Biochemistry. 2020 05 19; 59(19):1832-1844.

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Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 12 04; 57(48):6726-6734.

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Lieb DC, Brotman JJ, Hatcher MA, Aye MS, Cole BK, Haynes BA, Wohlgemuth SD, Fontana MA, Beydoun H, Nadler JL, Dobrian AD. Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes. J Clin Endocrinol Metab. 2014 Sep; 99(9):E1713-20.

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